About the Projects.
Electrochemical fluorination in Collaboration with AstraZeneca (Dr Kevin Lam / Dr Xacobe Cambeiro)
Organofluorine compounds display unique physical, chemical and biological properties compared to their hydrogenated analogues. Therefore, it is not surprising to find numerous fluorinated molecules among the top best-selling drugs.1 However, the installation of a fluorine atom remains far from being trivial. Hence, this project proposes developing a new practical, cheap, scalable and green method for the electrofluorination of aliphatic and aromatic compounds.
Supramolecular control of selectivity in HAT catalysis with GSK (Dr Ana Castilla / Dr Xacobe Cambeiro)
Photocatalytic C-H functionalisation methods based on hydrogen atom transfer are emerging as a promising addition to the medicinal chemist toolbox, facilitating and accelerating synthesis and enabling strategies for late-stage derivatisation. However, the enormous potential of these methods is lessened by their lack of selectivity, which poses severe obstacles to their application in complex settings.
We propose a strategy to develop highly selective photocatalytic C-H functionalisation methods using supramolecular chemistry. This approach will allow the development of catalyst libraries based on molecular recognition tailored for different selectivities.
We are now looking for highly motivated PhD students to join our team.
The projects would suit students with a strong background in synthetic chemistry. In addition, an interest in supramolecular chemistry, medicinal chemistry, photochemistry or electrochemistry would be an advantage.
The Students will be supervised by Dr Ana Castilla, Dr Xacobe Cambeiro or Dr Kevin Lam (http://www.lamresearchgroup.com). They will join a group of young, international and dynamic researchers!
The Research Group is housed within a newly refurbished laboratory and is very well equipped with more than 14 Electrasyns 2.0, an electrochemical and photochemical flow system, a glovebox, a solvent purification system, a dedicated GC-MS and HPLC-MS as well as several automatic chromatography systems, numerous photoreactors, etc.
The university will also provide the Students with routine access to 4 NMR spectrometers, several UPLC-MS, high-resolution mass spectrometers, etc.
How to Apply?
Please send a copy of your CV to k.lam 'at' greenwich.ac.uk
Interviews will start immediately, and the position might close as soon as a suitable candidate has been identified