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3D Nanozymes: Fabrication and assembly of the first hybrid enzymes

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  • Full or part time
    Dr A Fernandez-Mato
    Dr S Kondrat
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Many natural enzymes participate in chemical reactions which have commercial or medical value, and for which we have no good catalysts that can catalyse such reactions with the same precision and efficiency as enzymes. But natural enzymes are very fragile and can’t stand harsh conditions. This project will fabricate hybrid enzymes that can overcome the disadvantages of natural enzymes. In this project you will have the chance to work and collaborate with world-leading experts in the field. The candidate will be provided with full training in techniques like NMR, X-ray Crystallography and IR.

Loughborough University is a top-ten rated university in England for research intensity (REF2014). In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.
Find out more: http://www.lboro.ac.uk/study/postgraduate/supporting-you/research/

The Department of Chemistry at Loughborough University currently comprises 26 research active members of academic staff, 60 PhD students together with visiting/Emeritus academics and some 20 members of technical, secretarial and support staff. The department is very well equipped to carry out research spanning all the traditional branches of chemistry (analytical, inorganic, organic, bioorganic and physical).

Full Project Detail

Enzymes are by far the most proficient catalysts, mastering fundamental chemical transformations in all living organisms. This catalytic proficiency applied to industry would result in a drastic increase in efficiency, making the chemical processes more economic and sustainable. But all this potential has been hampered mainly due to the lack of stability and reusability. Therefore, the design of robust artificial enzymes that mimic enzyme activity could uncover the immense potential of natural enzymes. The project proposed here will allow to design a hybrid enzyme or Nanozyme by 3D assembling the catalytic core of a natural enzyme within an artificial porous material. 3D Nanozyme will represent the first truly mimic of an enzymatic active site, considered as one of the holy grails in catalysis. The 3D Nanozyme fabrication method will also allow to design innovative catalytic cores using unnatural amino acids with new and robust catalytic functions.

Find out more

http://www.lboro.ac.uk/science/study/postgraduate-research/studentships/
Email: [Email Address Removed]

Entry requirements

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Chemistry or a related subject.

How to apply

Applications should be made online at http://www.lboro.ac.uk/study/apply/research/. Under programme name, select CHEMISTRY.

Please quote reference number: AFM/CM/2019.

Funding Notes

This studentship will be awarded on a competitive basis to applicants who have applied to this project and/or any of the advertised projects prioritised for funding by the School of Science.

The 3-year studentship provides a tax-free stipend of £14,777 (2018 rate) per annum (in line with the standard research council rates) for the duration of the studentship plus tuition fees at the UK/EU rate. International (non-EU) students may apply however the total value of the studentship will be used towards the cost of the International tuition fee in the first instance.



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