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A 4-year PhD to uncover the drivers of Non-Alcoholic Fatty Liver Disease progression using patient derived organoids


   Biological Sciences

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  Dr Nicole Prior  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

The Project

Within the Southampton NIHR: National Institute for Health and Care Research Biomedical Research Centre, we are internationally regarded for the high quality of our translational research in nonalcoholic fatty liver disease (NAFLD). NAFLD represents a spectrum of chronic liver diseases that ultimately increases the risk of liver failure and/or of primary liver cancer. Working with world-leading experts and surgeons at University Hospital Southampton we are establishing a laboratory-based project aimed at improving our understanding of the mechanisms driving disease progression toward end stage liver disease and developing strategies to reverse NAFLD. The project will use state-of the-art organoid, omic and imaging technologies to identify potential therapeutic strategies.

We are seeking a talented individual who is keen to undertake research in experimental medicine, incorporating pre-clinical biomedical approaches.

The skills required:

You will have laboratory experience at undergraduate level. Experience with cell and tissue culture, omic analysis and/or imaging would be a bonus. The supervisory team will deliver focused training, so a willingness to learn new approaches and ways of thinking is the most important skill required.

 You will undertake a series of studies that enable you to establish liver organoids derived from patient samples, to generate an accessible and scalable disease model in which to investigate mechanisms driving NAFLD progression at the cellular level. This would allow you to test gene functions implicated in NAFLD through multimodal approaches and to perform drug screening in vitro, aimed at treating liver disease.

 The candidate:

You are a UK graduate who has or expects to obtain at least an upper second-class degree or Masters in Biological/Biomedical Sciences or allied subjects. You will meet the University of Southampton’s person specification for PhD candidates, which incorporates a full equality, diversity, and inclusivity policy. Funding will cover fees and a stipend at current UK research council rates.

 The Supervisory Team:

Your supervisory team of world leading non-clinical and clinical scientists will be led by Dr Nicole Prior (Biological Sciences) and Prof Jaswinder Sethi (Medicine), with support from Dr Ryan Buchanan (Medicine) and Professor Chris Byrne (Medicine), bridging the NIHR Southampton Biomedical Research Centre and School of Biological Sciences at the University of Southampton. You will be based in the Faculty of Environment and Life Sciences at the University of Southampton. If you wish to discuss this project further, please contact Dr Nicole Prior ([Email Address Removed]).


References

The candidate:
You are a UK graduate who has or expects to obtain at least an upper second-class degree or Masters in Biological/Biomedical Sciences or allied subjects. You will meet the University of Southampton’s person specification for PhD candidates, which incorporates a full equality, diversity, and inclusivity policy. Funding will cover fees and a stipend at current UK research council rates.
The Supervisory Team:
Your supervisory team of world leading non-clinical and clinical scientists will be led by Dr Nicole Prior (Biological Sciences) and Prof Jaswinder Sethi (Medicine), with support from Dr Ryan Buchanan (Medicine) and Professor Chris Byrne (Medicine), bridging the NIHR Southampton Biomedical Research Centre and School of Biological Sciences at the University of Southampton. You will be based in the Faculty of Environment and Life Sciences at the University of Southampton. If you wish to discuss this project further, please contact Dr Nicole Prior (n.r.j.prior@soton.ac.uk).
The project is funded for 4 years and welcomes applicants from the UK who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at current research council rates.
Due to funding restrictions this position is only open to UK applicants.
Applications for a PhD in Biological Sciences should be submitted online at:
https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=7187&majr=7187&term=202223
please place Nicole Prior in the field for proposed supervisor.
General enquiries should be made to Dr Nicole Prior at N.R.J.Prior@soton.ac.uk. Any queries on the application process should be made to fels-pgr-apply@soton.ac.uk
Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified
The University of Southampton and the School of Biological Sciences both hold an Athena Swan Silver Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

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