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A behavioural intervention targeting physical activity - sustaining weight loss and type 2 diabetes remission following a very low calorie diet


   Musculoskeletal Science and Sports Medicine

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  Dr Kelly Bowden-Davies  No more applications being accepted  Funded PhD Project (Students Worldwide)

Manchester United Kingdom Epidemiology Medical Physics Neuroscience Sport & Exercise Science Physiology

About the Project

Reversal of type 2 diabetes (T2D), termed ‘remission’ can be achieved by a very low calorie diet (VLCD). This is most successful in individuals who are able to maintain the significant weight loss that is achieved through the diet. However, weight regain, which occurs in a large proportion of patients, is associated with a relapse in remission.

The purpose of this study is to investigate if an intervention to increase physical activity (PA) amongst T2D patients that have recently achieved remission (through VLCD) can sustain weight loss, and therefore remission. Patients who have recently achieved diabetes remission through VLCD will be recruited and randomised to an intervention or control group. The intervention group will receive a theory-based behavioural intervention targeting an increase in PA. Health assessments will be taken at baseline, 3 and 6 months follow-up and include: anthropometrics (weight, body mass index [BMI], hip/waist circumferences), blood pressure, body composition i.e. muscle mass and fat mass by dual-energy X-ray absorptiometry (DEXA), fasting bloods to determine diabetic control (e.g. glucose, insulin), fitness assessment (exercise test), as well as dietary assessment and quality of life questionnaires. PA (sedentary time, light activity etc.) will monitored for 7 days at each time point (GENEActive). 

This is part of a wider Masters by Research recruitment drive where the best four or five candidates across the projects will be appointed. Find out more about the Musculoskeletal Science and Sports Medicine Research Centre and see what other opportunities are available.


Funding Notes

This opportunity is one of six Masters by Research projects being advertised by the Musculoskeletal Science and Sports Medicine Research Centre. Funding is available for the four or five strongest applicants across the six projects which includes the equivalent of Home fees (one year, full-time Masters by Research) plus additional project costs, and does not include any stipends or the writing up fee.