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A biologic drug blocking ROR2 for disease modification in osteoarthritis


   Barts and The London School of Medicine and Dentistry

  Prof F Dell'Accio  Wednesday, July 20, 2022  Funded PhD Project (European/UK Students Only)

About the Project

We reported that silencing the WNT receptor ROR2 results in protection from cartilage breakdown and rapid pain relief in a murine model of osteoarthritis and in chondrogenesis in vitro and in vivo with human osteoarthritic chondrocytes (Thorup et al. Sci Transl Med 2020). We have now developed a recombinant molecule that that blocks ROR2 and is chondrogenic in vitro. With this application we want to further optimise this molecule to extend its half-life in vivo and we aim at providing efficacy data in animal models of osteoarthritis.

Applications should be sent directly to QMUL admissions via this link (choosing the category: PhD Full-time William Harvey Research Institute (non-clinical) Semester 1 (September Start)):

https://www.qmul.ac.uk/postgraduate/research/subjects/medicine-william-harvey-research-institute.html

The closing date for applications is Wednesday 20th July 2022, interviews will be thereafter. Start date is 1st September 2022


Funding Notes

This position will be funded for 3 years by Versus Arthritis, starting at £23,000

References

Thorup et al. Science Translational Medicine 2020. PMID: 32938794. https://pubmed.ncbi.nlm.nih.gov/32938794/

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