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Prof F Dell'Accio
Wednesday, July 20, 2022
Funded PhD Project (European/UK Students Only)
London
United Kingdom
Bioinformatics
Biotechnology
Cell Biology
Molecular Biology
Pharmacology
Toxicology
About the Project
We reported that silencing the WNT receptor ROR2 results in protection from cartilage breakdown and rapid pain relief in a murine model of osteoarthritis and in chondrogenesis in vitro and in vivo with human osteoarthritic chondrocytes (Thorup et al. Sci Transl Med 2020). We have now developed a recombinant molecule that that blocks ROR2 and is chondrogenic in vitro. With this application we want to further optimise this molecule to extend its half-life in vivo and we aim at providing efficacy data in animal models of osteoarthritis.
Applications should be sent directly to QMUL admissions via this link (choosing the category: PhD Full-time William Harvey Research Institute (non-clinical) Semester 1 (September Start)):
https://www.qmul.ac.uk/postgraduate/research/subjects/medicine-william-harvey-research-institute.html
The closing date for applications is Wednesday 20th July 2022, interviews will be thereafter. Start date is 1st September 2022
Funding Notes
This position will be funded for 3 years by Versus Arthritis, starting at £23,000
References
Thorup et al. Science Translational Medicine 2020. PMID: 32938794. https://pubmed.ncbi.nlm.nih.gov/32938794/
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