Metal-ligand catalysts are transforming synthetic chemistry by enabling the rapid, efficient and sustainable generation of target compounds. These compounds in turn find application in numerous fields, most notably in the discovery of new pharmaceuticals for the treatment of disease. Existing catalyst discovery and optimisation procedures are frequently time consuming, non-systematic, and limited by the commercial availability of suitable ligands. This project will develop a high-throughput, versatile and step-wise approach to catalyst discovery for application to the synthesis of novel, pharmaceutically relevant, compounds. It will exploit recent developments within the Richards group on ligand synthesis/metal capture procedures with metallacycles, and also on the methodology for step-wise generation of stereochemical complexity. This project will suit an individual with a strong interest in pharmaceutically relevant synthetic organic and organometallic chemistry. In addition to gaining expertise in many key areas of compound generation, the project will provide additional core skills in spectroscopic and chromatographic analysis, stereochemistry, molecular modelling and x-ray crystallography.