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A chemical biology approach to identifying cyclic peptide antibiotics

  • Full or part time
  • Application Deadline
    Saturday, August 31, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

We are seeking a talented and motivated scientist to work on a 3.5 year interdisciplinary PhD project in the field of chemical biology. The project is funded by a major US pharmaceutical company and will be conducted in the Tavassoli lab at the School of Chemistry, University of Southampton.

The Tavassoli lab have pioneered methods for the generation and screening of cyclic peptide libraries. The approach, called SICLOPPS, has led to the identification and development of a number of first in class inhibitors; for a review see: https://www.sciencedirect.com/science/article/pii/S1367593116301818

The aim of this project is to use SICLOPPS for the discovery of new antibiotics. This requires the development of a new platform and approach for deploying SICLOPPS libraries. The work is funded by and will be conducted in close collaboration with a major US pharmaceutical company.

The ideal candidate will have prior lab-based experience of chemical biology and/or molecular biology. However, this isn’t essential, and training in molecular biology will be provided as part of the PhD.

More information about the Tavassoli lab can be found on the University of Southampton website :
https://www.southampton.ac.uk/chemistry/about/staff/ali1.page

Please feel free to contact Ali by email if you have any questions or would like to discuss the opportunity informally.

Funding Notes

This 3.5 year studentship covers UK tuition fees and provides an annual tax-free stipend at the standard EPSRC rate, which is £14,777 for 2019/20.

Applicants must be UK or EU residents with no restrictions on how long they can stay in the UK and have lived here for at least 3 years prior to the start of the studentship. This residence cannot be mainly for the purpose of receiving full-time education.

For further guidance on funding, please contact

How good is research at University of Southampton in Chemistry?

FTE Category A staff submitted: 44.80

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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