£6,000 PhD Scholarship | APPLY NOW £6,000 PhD Scholarship | APPLY NOW
Gdansk University of Technology Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

A high-throughput library approach for minimizing peptide off-targets

   Institute of Chemical Biology

This project is no longer listed on FindAPhD.com and may not be available.

Click here to search FindAPhD.com for PhD studentship opportunities
  Dr L Walport, Dr B Schumann  Applications accepted all year round  Funded PhD Project (UK Students Only)

About the Project


Recent breakthroughs in oral peptide delivery have vastly extended the chemical space which is available to drug protein/protein interactions and other challenging targets. High throughput techniques such as mRNA display that allow screening of enormous libraries of DNA encoded peptides are perfectly suited to provide clinical candidates of this kind. However, in contrast to more standard small molecules, de novo peptides carry an increased risk of engaging off-targets, leading to less effective drugs and higher attrition rates during the drug discovery process. Consequently, innovative technologies to address these challenges are critically needed. In this project we will develop a streamlined mRNA-display-based approach to identify and subsequently minimize peptide off-targets using a photo-affinity labelling strategy. Complementary data from next generation DNA sequencing and mass spectrometry will enable sophisticated in silico optimization of hit peptide sequences. The project will involve learning and applying a diverse range of modern chemical biology approaches, from peptide chemistry to proteomics, and AI and in silico design to cell biology. This project is a collaboration with Novo Nordisk and would ideally suit a student with a strong chemistry or chemical biology background and an interest in working with industry. Previous knowledge of high throughput technologies including peptide synthesis and analysis would be an advantage.

Funding Notes

UK residents or EU settled/pre-settled status can apply.
Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.

PhD saved successfully
View saved PhDs