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A new class of anti- tuberculosis drugs: Design and synthesis of MetX inhibitors


Ferrier Research Institute

, , Dr Wanting Jiao Applications accepted all year round Funded PhD Project (Students Worldwide)

About the Project

The project is designed to maximise the chance of developing a successful drug to treat Tuberculosis by using enzymatic transition-state analysis. This powerful technique effectively provides a blueprint for the design of potent enzyme inhibitors by describing enzyme transition-state features. We are using a computational approach to determine MetX transition-state, the enzyme involved in the targeted Mtb pathway. This project will involve the design, synthesis and testing of potential enzyme inhibitors. 

This is a cross-disciplinary project involving elements of synthetic organic chemistry, analytical chemistry and inhibitory activity assays. In this project, you will gain experience in the synthesis of small molecules and become proficient using the associated characterisation techniques (LC-MS, NMR etc). If interested, you could also be involved in the design of potential inhibitors using the computational approach. This project will thus allow you to master a broad range of skills. 


Funding Notes

The Stipend is NZD $27,500 pa and full fees will be paid. It is essential that the successful applicant has a background in organic chemistry. Applicants will have a BSc (Hons), MSc or equivalent degree in chemistry with a focus on organic chemistry. International applicants will require to fill an exemption form to enter the country and meet Victoria University of Wellington English language requirement.
When applying please ensure all required documents are attached:
• All degree certificates and transcripts (Undergraduate AND Postgraduate MSc-officially translated into English where necessary)
• Detailed CV
• Details of 2 academic referees

References



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