About the Project
The project is designed to maximise the chance of developing a successful drug to treat Tuberculosis by using enzymatic transition-state analysis. This powerful technique effectively provides a blueprint for the design of potent enzyme inhibitors by describing enzyme transition-state features. We are using a computational approach to determine MetX transition-state, the enzyme involved in the targeted Mtb pathway. This project will involve the design, synthesis and testing of potential enzyme inhibitors.
This is a cross-disciplinary project involving elements of synthetic organic chemistry, analytical chemistry and inhibitory activity assays. In this project, you will gain experience in the synthesis of small molecules and become proficient using the associated characterisation techniques (LC-MS, NMR etc). If interested, you could also be involved in the design of potential inhibitors using the computational approach. This project will thus allow you to master a broad range of skills.
When applying please ensure all required documents are attached:
• All degree certificates and transcripts (Undergraduate AND Postgraduate MSc-officially translated into English where necessary)
• Detailed CV
• Details of 2 academic referees
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