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A non-invasive robotic capsule for oral delivery of peptides and proteins


Institute of Pharmaceutical Science

Applications accepted all year round Self-Funded PhD Students Only

About the Project

In the last decade, an increasing number of biologics received FDA approval. Delivering these molecules orally provides a plethora of obvious advantages for both patients and healthcare providers. Despite the increasing interest in the oral route, the oral delivery of biologicals remains a major challenge for pharmaceutical industry. This could be attributed to several hurdles such as poor absorption across gut as poor absorption, hostile environment of the stomach and enzymatic degradation in small intestine. Moreover, temperature, pH and possibly light may also impact peptide and protein structures during manufacturing. On the other hand, there is a growing interesting of using additive manufacturing (a.k.a. 3D printing) for production of personalised dosage forms, implants, stents. More recently, 3D printing was reported to produce liquid filled capsule with customizable dose and drug release pattern. This project aims to develop a non-invasive robotic approach based on 3D printing for enhancing oral delivery of peptides and proteins.
The project will involve experimenting different design concepts of robotic capsule units equipped with non-invasive drug release mechanism. The fabrication and functionality testing of these 3D printed robotics will be tested and the stability of protein payload and the leave of its penetration will be assessed in vitro using simulated permeability and dissolution models as well as in vivo.

Person specification
We are looking to recruit ambitious and motivated graduates to address this ground-breaking research for fabrication and functionalisation of next generation oral delivery systems for proteins.

Research training
The student will have valuable learning opportunities on various formulation skills such as CAD design, 3D printing, Pharmaceutical Material adaptation, dosage form quality control, protein formulation, permeation studies and in vivo evaluation of oral bioavailabilty.

Dr Alhnan has a leading expertise in pharmaceutical additive manufacturing https://kclpure.kcl.ac.uk/portal/alhnan.html https://scholar.google.com/citations?user=boaKXLsAAAAJ&hl=en

Informal enquiries should be directed to Dr Mohamed A Alhnan:



Funding Notes

Applications are welcome year-round from Home/EU/Overseas self-funded students and applicants able to secure funding to cover all costs involved with PhD study, including living costs, tuition fees (and bench fees where required).

References

Research programme profile
https://www.kcl.ac.uk/study/postgraduate/research-courses/cancer-and-pharmaceutical-sciences-mphil-phd

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