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A novel approach to developing rechargeable fluoride containing polymeric dental materials


Project Description

Background:
Fluoride has the potential to inhibit caries by promoting remineralisation of carious lesions and acid eroded enamel. The presence of fluoride in the mouth in a sustained low level is considered to be the most effective method in dental prophylaxis and fighting caries. Therefore, some commercial polymeric dental restorative materials aim to release fluoride at the tooth surface. The major drawback with these materials is the inability to replenish their fluoride store, thus leaving them devoid of fluoride after a short period of time; they do not have the ability to recharge once they have released their fluoride content.

This project is based on developing novel and experimental polymeric dental materials, acting as fluoride rechargeable systems, with the incorporation of layered double hydroxides (LDHs). LDH consists of positively charged inorganic matrices, arranged in sheets, counterbalanced with the intercalation of anions within those hydrated interlayers. LDHs have proven to be successful in removal of excess fluoride from drinking water; they are also utilised in the controlled release of pharmacologically active compounds. The success of these LDH fluoride battery systems will have a huge impact in the dental field in fighting caries, the number one cause of tooth failure. The outcome of this project should lead to product(s) approaching the marketing stage.

Aims:
• To synthesise and incorporate LDHs into a variety of commercial and experimental polymeric dental materials and to test their ability to act as rechargeable fluoride systems, maintaining an optimal low level of fluoride necessary in the mouth.
• To study the physicomechanical properties of these materials before and after releasing fluoride, after recharging and re-releasing fluoride.

How to apply:

For more information regarding the project, please contact Dr Mangala Patel ( )

Applications should be submitted through the Queen Mary application system. Please indicate the project title and supervisor in the ‘Research Degree Programmes - Additional Questions’ section of the application.

Alongside the application form, please send the following supporting documents:
• Curriculum Vitae (CV)
• Copies of your degree certificates with transcripts
• Proof of English language ability for overseas applicants from non-English speaking countries
• A one-side A4 statement of purpose. This should set out your previous academic or other experience relevant to the proposed research; why you wish to undertake this research at QMUL; your previous research or professional training and what further training you think you will need to complete a PhD; and what ethical issues you will need to consider in undertaking this research.
• Two references. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.

Please contact Charlotte Royle () with any queries about the application process.

Funding Notes

Person specification:
The project would suit a candidate with a BDS or a minimum of 2:1 degree in Biomedical Sciences, Dental Materials, biochemistry, Chemistry or Physical Sciences.

Funding notes:

We will consider applications from prospective students with a source of funding to cover tuition fees and bench fees. Both self-funded and sponsored students will be considered.

UK and EU nationality self-funded students might be eligible for both the cost of tuition fees and a yearly stipend over the course of the PhD programme from the Student Finance England: View Website

How good is research at Queen Mary University of London in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 32.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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