About the Project
Anticholinergic burden occurs when one or more drugs with anticholinergic properties are co-administered. Numerous studies have reported that the anticholinergic burden is a strong predictor of cognitive impairment. The permeability of the blood-brain barrier, as well as altered sensitivity of muscarinic receptors, are some of the critical factors that contribute to cognitive burden.
The current scales tend to simplify the complexity of pharmacological mechanisms of drugs with anticholinergic properties. Importantly, there is no easy way of measuring how well a drug crosses the blood-brain barrier. This property is complex and multifaceted when predicting cognitive outcomes from taking multiple drugs with anticholinergic properties.
We propose to develop a novel anticholinergic burden tool based on pharmacokinetic and psychochemical data. An application will be designed to recognise the potential iatrogenic risk of taking multiple drugs with anticholinergic properties. The application will aid clinicians in improving prescribing for older people.
Applicants should hold, or expect to receive, a First Class or Upper Second Class UK Honours degree (or the equivalent qualification gained outside the UK) in a relevant subject. A master’s level qualification from the disciplines of statistics, pharmacy or medicine would also be advantageous.
Applicants should submit their CV and a one-page expression of interest statement on how their research interests align with pharmacoepidemiology and pharmacokinetics to Dr Prasad Nishtala on email address [email protected].
2. Nishtala PS, Salahudeen MS, Hilmer SN. Anticholinergics: Theoretical and Clinical Overview, Expert Opinion in Drug Safety, 2016; 30:1-16.
3. Nishtala PS, Fois RA, McLachlan AJ, Bell JS, Kelly PJ, Chen TF. Anticholinergic activity of commonly prescribed medications and neuropsychiatric adverse events in older people. Journal of Clinical Pharmacology. 2009; 49; 1176-84.
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.