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A Novel Dietary Approach for Functional Bowel Disorders

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  • Full or part time
    Prof N Bury
    Dr Fandi Ibrahim
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Functional bowel disorders (FBDs) of various forms and severity affect millions of people in the UK, and the WHO estimates around 20% worldwide. Some of these are severe enough to be classed as Irritable Bowel Syndrome (IBS), and some may be less frequent but they may still impact severely on the quality of life. Some inborn metabolic errors go undiagnosed or misdiagnosed as IBS such as sucrose-isomaltase deficiency. People with functional bowel disorders often exhibit lower gastrointestinal symptoms such chronic constipation, diarrhoea, alternate periods, bloating, excessive gas production, and abdominal pain with no pathological origin.

There are a few dietary approaches to assist people with FBDs and the most common are the low FODMAP diet and the gluten-free diet, and these have various limitations, including the complexity of delivery and concerns of their long-term nutritional adequacy. Therefore, we have recently developed a novel approach, i.e. 5Ad Dietary Protocol, and expressed our view that FBDs are a spectrum of a wider food intolerances caused by extrinsic dietary factors in the susceptible individuals due to pre-post agriculture dietary changes that have not been matched with genetic adaptions (Nutrients 2019, 11(8), 1938 and Nutrients 2020, 12(1), 140).
This PhD project aims to conduct a randomized clinical trial (RCT) using a sham protocol to verify the previous findings observed of with the 5Ad Dietary Protocol in a repeated measure design, and to propose and generate novel ways of FBDs diagnosis.
The PhD candidate, with guidance from the supervisors, will be responsible for the necessary communication with the relevant RCT partners, and will be designing, performing and analysing the proposed RCT as well as writing, publications, and other forms of dissemination.

For more information on the supervisors for this project please go to:
Primary Academic Supervisor: Nic Bury https://www.uos.ac.uk/people/professor-nic-bury
Associate supervisor: Fandi Ibrahim https://www.uos.ac.uk/people/dr-fandi-ibrahim

Type of programme: PhD

Start date of project: October 2020

Mode of study: full time

Length of studentship: 4 year funded period

Location: Ipswich Campus

Funding Notes

The University of Suffolk are pleased to offer this project as a fee waiver scholarship. The cost of your PhD fees will be covered by the University, however living costs will need to be considered and accounted for by the candidate.

References

• Fandi Ibrahim and Philippa Stribling. A 5Ad Dietary Protocol for Functional Bowel Disorders, Nutrients 2019, 11(8),1938
• Reply to “A Gluten Reduction Is the Patients’ Choice for a Dietary ‘Bottom Up’ Approach in IBS—A Comment on “A 5Ad Dietary Protocol for Functional Bowel Disorders” Nutrients 2019, 11, 1938”
• Dionne, J.; Ford, A.C.; Yuan, Y.; Chey, W.D.; Lacy, B.E.; Saito, Y.A.; Quigley, E.M.M.; Moayyedi, P. A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPS Diet in Treating Symptoms of Irritable Bowel Syndrome. Am. J. Gastroenterol. 2018, 113, 1290–1300.
• Drossman, D.A. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Gastroenterology 2016, 150, 1262–1279.
• De Giorgio, R., Volta, U. and Gibson, P.R. (2016) ‘Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?’, Gut, 65(1), pp. 169-178

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