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A single cell biopsy platform to study dynamic transcriptional changes in cancer

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  • Full or part time
    Dr J Edel
  • Application Deadline
    Applications accepted all year round

Project Description

Funded by the CDT in Chemical Biology: Innovation in Life Sciences – 1+3 year PhD studentships

Supervisors: Professor Joshua B Edel | Dr Luca Magnani | Dr Alex Ivanov

The current dogma is that individual cancers change via classical Darwinian evolution operating on genetically heterogeneous cancer populations. However recent developments in single-cell technologies suggest that individual cells can have different trajectories independently from genetic events, mostly via quick transcriptional adaptation. A considerable limitation of single-cell technologies is the inability to measure the exact same cells over time. Thus, all measurements are by definition correlative and strongly limit data interpretation. Our team will address this fundamental limitation by developing a cellular biopsy to dynamically measure the transcriptome of individual cancer cells over extended periods. JBE and AI will build on a recently developed nanotweezer able to capture cytoplasmic nucleic acids in living cells, while LM has developed an assay to track the evolution of single cells. In this multidisciplinary project, the CDT student will apply this collective expertise to develop a novel platform to perform high-throughput cellular biopsies and dynamically measure RNA transcription in cancer cells during early oncogenesis and clinical treatment.

Funding Notes

Applications are encouraged as soon as possible, since positions will be filled as soon as suitable candidates are found.
To see our other projects, our eligibility criteria, and to find out how to apply, please visit our studentships page: http://www.imperial.ac.uk/chemical-biology/cdt/studentships/entry-2019/
For more information about our CDT please visit our CDT homepage: http://www.imperial.ac.uk/chemical-biology/cdt/

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FTE Category A staff submitted: 54.90

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