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  (A*STAR Split-site) Engineering non-coding RNAs (ncRNAs) in eukaryotic genomes using synthetic genomic approaches


   Department of Chemistry

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  Prof Patrick Cai, Dr Chew Wei Leong  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

We are entering the exciting new age of synthetic biology. Recent technological breakthroughs present big opportunities in synthesizing DNA from scratch, building DNA into radically designed genomes, editing genes within living cells, and investigating how new biological functions emerge from these massive changes. This project capitalizes on the deep technological expertise of the Cai and Chew Labs in DNA engineering to design new human genomes. The candidate will undertake training in synthetic genomics and perform high throughput synthetic DNA design, synthesis and assembly in the Cai lab at Manchester, and conduct multiplex human genome engineering in the Chew Lab at Singapore. We will investigate how these synthetic human genomes produce novel biological functions within human cells and/or mini human organs (organoids). The novel technologies to be developed in this project and the significant implications of this work represent a grand challenge in our understanding of fundamental human genetics.

Eligibility

Applicants should have, or expect to achieve, at least a 2.1 honours degree or a master’s in a relevant science or engineering related discipline.

Funding

 Scholarships are available for suitable candidates to commence on this 4-year programme in October 2024 including:

·        Tuition fees

·        Annual stipend at the minimum UKRI rate (2023/24 rate £18,622) to the students when in Manchester (for a maximum of 2 years) and when in A*STAR (two years) equivalent to S$2,700/month.

·        Flight allowance for students travelling to Singapore (£1,000) paid by University of Manchester.

·        One return airfare to/from Singapore (S$1,500) paid by A*STAR

·        Medical insurance and settling-in allowance (S$1,000) paid by A*STAR

·        An annual Research Training Support Grant (RTSG) towards project running costs/consumables (up to £5,000 pa) provided to all students when in Manchester.

·        Supervisor travel allowance up to £6,000 for two airfare/accommodation visits to Singapore. 

Before you apply

We strongly recommend that you contact the supervisor(s) for this project before you apply.

How to apply

To be considered for this project you’ll need complete a formal application through our online application portal.

When applying, you’ll need to specify the full name of this project, the name of your supervisor, how you’re planning on funding your research, details of your previous study, and names and contact details of two referees.

Your application will not be processed without all of the required documents submitted at the time of application, and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered.

If you have any questions about making an application, please contact our admissions team by emailing

[Email Address Removed]

Equality, diversity and inclusion

Equality, diversity and inclusion are fundamental to the success of The University of Manchester, and are at the heart of all of our activities. We know that diversity strengthens our research community, leading to enhanced research creativity, productivity and quality, and societal and economic impact.

We actively encourage applicants from diverse career paths and backgrounds and from all sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation and transgender status.

We also support applications from those returning from a career break or other roles. We consider offering flexible study arrangements (including part-time: 50%, 60% or 80%, depending on the project/funder).

Biological Sciences (4) Engineering (12)

Funding Notes

For funding information, see Project Description

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