About the Project
GJH is common in teenagers: 1 in 10 boys and 1 in 3 girls at aged 14. However, there are many important unanswered questions. The Avon Longitudinal Study of Parents and Children (ALSPAC) has data on hypermobility at age 14 and 17, along with detailed information on pain, other symptoms such as irritable bowel syndrome and anxiety/depression, as well as genetic data which will allow novel analyses of potential confounders such as obesity.
The overall aim of this PhD is to describe the natural history of hypermobility between age 14 and 17, and to identify if change in hypermobility status impacts on symptoms. Specifically:
1. To be the first to describe the natural history of musculoskeletal hypermobility between ages 14 and 17, and to stratify participants into relevant subgroups.
2. To investigate the association between subgroups and pain, and to explore the influence of obesity. This will start with a logistic regression approach and will utilise the genetic risk score for variation in adiposity.
3. To explore clustering of symptoms such as fatigue, irritable bowel syndrome, anxiety/depression and subgroups of hypermobility. This will use CART analysis followed by a hierarchical cluster analysis and K-means clustering.
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