Overexpression and somatic mutations can lead to a hyperactivation of certain tyrosine receptor kinases in cancers, such as epidermal growth factor receptor (EGFR) and Hepatocyte growth factor receptor (cMET). This has been evident in different solid tumours, including lung cancer, gastric cancer, colon cancer and breast cancer. There is unmet need for failure of targeting TRKs in cancers. For instance, overexpression of EGFR is frequently observed in both gastric cancer and triple negative breast cancer (TNBC) which is associated disease progression, drug resistance and relapse of the diseases. Clinical trials of targeting EGFR have not shown obvious benefit to the patients. Our recent studies revealed deregulated bone morphogenetic proteins (BMP) and their signalling has an intimate link with EGFR signalling in gastric cancer. The proposed research aims to dissect specific links and involvement of BMP signalling in TRKs promoted disease progression and drug resistance in solid tumours for developing marker and target for more precise target therapy.
We are seeking enthusiastic and motivated students with an interest in Cancer or genomic research. Applicants should possess a minimum of an upper second-class Honours degree, master's degree, or equivalent in a relevant subject.
Applicants whose first language is not English are normally expected to meet the minimum University requirements (e.g. 6.5 IELTS)
The total duration of this PhD programme is 3 years. Following discussion with proposed supervisors and to be considered you must submit a formal application via Cardiff University’s online application service. Medicine - Study - Cardiff University
There is a box at the top right of the page labelled ‘Apply’, please ensure you select the correct ‘Qualification’ (Doctor of Philosophy), the correct ‘Mode of Study’ (Full Time) and the correct ‘Start Date’ (i.e. October 2022). This will take you to the application portal.
In the ‘Research Proposal’ section of the application enter the name of the project you are applying to.
Candidates must submit the following information:
- Supporting statement
- Qualification certificates
- Proof of Funding i.e. a letter of intent from your sponsor or confirmation of self-funded status.
- References x 2
- Proof of English language (if applicable)
Closing date for applicants is 31st March 2022.