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  Active transport of Gold-coated iron oxide superparamagnetic nanoparticles: A universal delivery vehicle.


   Graduate School

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  Prof Chris Gwenin, Dr A Spiers  Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

The pan-University Graduate School offers an integrated training programme to the postgraduate community within a single centre, serving to inculcate interdisciplinary working in our next generation of researchers. 

Interviews are likely to be online in August 2022

Project Description:

The overarching aim for the project is to develop a novel delivery vector which has the capacity to deliver drug/ treatment methods to a specific site within the body. The project will be focused on the use of gold-coated iron oxide nanoparticles combined with transport protein/ cell-penetrating peptides which can be conjugated to the nanoparticle. Further coupling of this with cargo such as a prodrug/ enzyme, could provide a solution to the issue that faces treatment methods such as DEPT, where cellular uptake often dictates performance. These synthesised particles are unique and produced within our research group as no other source exists.

Objectives

This project sets out to answer the fundamental questions of stability, biocompatibility and toxicology for a new drug delivery platform for cancer and we aim to produce a high quality well rounded multidisciplinary researcher.

It is anticipated that the output of this research be of widespread and significant benefit to the research community and industry. Research findings would be disseminated through academic publications and conferences where the student will be able to engage with other researchers. General research-associated and career development training opportunities will be available through the Graduate School, including opportunities to engage with undergraduate teaching.

Supervisory Team:

The candidate will be supervised by Prof. Chris Gwenin and Dr Andrew Spiers. Queries should be directed to Prof Chris Gwenin ([Email Address Removed]).

Applications and closing date: until filled

Applicants should complete an online Research Student Application Form. Please submit a personal statement of application detailing why you are interested in undertaking this project (instead of a research proposal) along with your CV.

Abertay University was named The Times and The Sunday Times University of the Year for Teaching Quality 2021. According to the results of the Research Excellence Framework 2021, Abertay recorded 60% of its research judged as 'internationally excellent' or 'world-leading', a 23% increase since the last REF2014 – the biggest climb of any Scottish university.

We hold an Athena SWAN Institutional Bronze award and were the first Scottish university to achieve the Race Equality Charter Mark.

Essential Requirements

  • First class or upper second-class Honours degree in a chemistry or biology accredited programme or a closely aligned discipline. 
  • Experience in experimental design, laboratory work, data analysis and presentation.
  • Good scientific writing.
  • Good numerical and statistics skills and familiarity with text editing software, such as Word, Excel, etc.
  • Good interpersonal and communication skills.
  • No previous criminal record that prohibits work with children (prospective candidate may have to successfully apply to the PVG scheme after commencement of their PhD if undertaking this kind of work).
  • Applicants who are non-native speakers of English, the University requires IELTS of 6.5 (with no band less than 6.0) or an equivalent qualification accepted by the Home Office.

Desirable requirements (but not essential)

  • Master of Science level qualification in a relevant discipline.
  • Involvement in the preparation of articles for publication in scientific journal(s).
  • Knowledge of advanced statistical methods.
Biological Sciences (4) Chemistry (6) Mathematics (25)

Funding Notes

A PhD studentship that comprises tax-free stipend of £16,062 per year over 3.5 years (increasing in line with UKRI per annum), student tuition fees paid, and a generous study package with limited research consumables, travel budget, and training when appropriate.
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