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AdaptaLox: Adaptation of bacteria to low oxygen environment in chronic lung disease

   The Conway Institute of Biomolecular and Biomedical Research

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  Dr S McClean  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

We are seeking a motivated and enthusiastic PhD candidate to join our research team. The project will investigate the changes that bacteria undergo as they adapt to the lung and the low oxygen environment associated with chronic infection.  This is a Science Foundation Ireland (SFI)-funded PhD scholarship with funding for four years, including PhD stipend and EU tuition fees. 

Chronic lung infections are associated with poor quality of life and mortality for people with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The process of chronic colonisation allows pathogens to evolve and adapt over time to cope with changing selection pressures, co-infecting species and antimicrobial therapies. The mechanisms behind this bacterial evolution are poorly understood. The aim of this project is to investigate the adaptive mechanisms that bacterial pathogens undergo during chronic colonisation. This PhD  project will involve a range of techniques including microbiology, cell biology, proteomics, transcriptomics, cloning, mutagenesis, protein:protein interactions and examination of host-pathogen interactions. 

Qualifications:  Applicants should have a BSc (Hons) or MSc in a relevant biomedical discipline, e.g. Biochemistry, Microbiology , Biotechnology (minimum award 2.1);  or should expect to graduate in 2022 with a BSc Hons or MSc and a track record indicative of  a 2.1 award or higher.

Skills and Interests:  The ideal candidate will have a passion for biomedical research. He/She will ideally have experience in cell culture, microbial cell culture or proteomic analysis.  The successful applicant will work in a large multidisciplinary team and a demonstrated ability to work as part of a team is essential.  Candidates should also demonstrate strong communication skills and a high level of initiative and organisation. 

How to apply:

Applications should be sent to Assoc. Prof. Siobhán McClean (UCD Conway Institute and School of Biomolecular and Biomedical Science) by email [Email Address Removed]

·  Please include a 1-page Cover letter that describes your interest in this project and your experience in cell biology, infection biology, proteomics or other related areas. 

·  Please include a short 2 page CV with the names and contact details of two referees. 

Closing date for applications: February 25th 2022

We value gender balance and are committed to creating a diverse environment. All qualified applicants will receive equal opportunities and consideration for this scholarship

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