The Centre for Sustainable Chemical Technologies (CSCT) at the University of Bath has now launched a new joint PhD programme with Monash University, Australia. The Bath Monash Global PhD Programme will have its first intake in October this year.
This project is one of a number that are in competition for up to four funded studentships. More details are available here: http://www.csct.ac.uk/study-with-us/
Home institution: Monash University
Supervisor at Bath: Dr Matthew Grayson
Supervisor at Monash: Professor David W Lupton (lead)
Enantioselective organocatalysis has evolved rapidly and now provides access to a dizzying array of functional materials. Beyond the academic lab organocatalysis being exploited to solve problems in industry. For example, Merck recently employed an amine catalysed Michael addition in the penultimate step of the commercial route to Letermovir, an approved antiviral for cytomegalovirus infections.
Despite significant attention a range of fundamental questions in this field remain. Drawing from recent experiences from the Lupton lab (Monash University) this collaborative project aims to exploit advanced theoretical computational approaches (Grayson, University of Bath), combined with physical organic chemistry to address a series of puzzles common to the field. It is envisaged that based on the interests of the student studies in this project can be focused from fundamental theoretical chemistry, through to physical organic chemistry, and enantioselective reaction discovery. For the computational studies, no prior molecular modelling experience is required. Training can be provided in the use of computational methods to model chemical reactions, a skill useful across all areas of the chemical sciences in both academic and industrial settings. Training in Python, a broadly used and general-purpose programming language, will also be provided for those interested though no programming is necessary for the project.
Specifically, we will focus on two significant problems:
1. Entropy controlled enantioselective transformations. While enantiodetermining transition states of many reactions are thought to be largely controlled by enthalpy in a number of cases they appear to be entropically controlled, resulting in reactions that are more enantioselective at higher reaction temperatures. While conceptually this can be rationalised, the detail regarding why this is the case, and indeed how this can be exploited to deliver improvements in synthesis, are yet to be developed. Computational methods will be used to calculate the structure and free energy of the transition states of such reactions which will provide a detailed insight into the entropic and enthalpic contributions to the observed selectivity. These insights will then enable rational design of new reactions.
2. Electronic sensitivity of enantioselective transformations. The impact of the electronic demand of substrates on enantioselectivity is not fully appreciated. In this topic, we will examine a number of reactions that show profound sensitivity to electronic demand. Does an enhanced understanding on this phenomenon allow the design of new catalysts to overcome these limitations? Computational methods will again be used to understand these observations and to make predictions about the likely selectivity that can be achieved with new generation catalysts.
We invite applications from Science and Engineering graduates who have, or expect to obtain, a first or upper second class degree and have a strong interest in Sustainable Chemical Technologies.
You may express an interest in up to three projects in order of preference. See the CSCT website for more information: http://www.csct.ac.uk/study-with-us
Please submit your application at the Home institution of your preferred project. However, please note that you are applying for a joint PhD programme and applications will be processed as such.
If this is your preferred project, apply to Monash here: https://docs.google.com/forms/d/e/1FAIpQLSd4RT7A62PF6DSqLQLNFBUltFIHv1Cf12oI_CKY_Op8-k3XPw/viewform
If the Home institution of your preferred project is Bath, apply here: https://samis.bath.ac.uk/urd/sits.urd/run/siw_ipp_lgn.login?process=siw_ipp_app&code1=RDUCH-MO01&code2=0001
Please quote ‘Bath Monash PhD studentship’ in the Finance section and the lead supervisor(s)’ name(s) and project title(s) in the ‘Your research interests’ section. More information on applying to Bath may be found here: https://www.bath.ac.uk/guides/how-to-apply-for-doctoral-study/
Enquiries about the application process should be sent to [email protected]