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Addressing the functional significance of distinct paths to catalytic sites within the exosome

Department of Molecular Biology and Biotechnology

Dr P Mitchell Applications accepted all year round Self-Funded PhD Students Only

About the Project

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014). Substrates can be targeted to these enzymes along a number of multiple pathways. Which RNA substrates utilise which pathway? Is there an obligatory or stochastic choice of pathway for a given RNA? Is the flux through a given pathway subject to regulation through growth conditions?

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit to learn more.

Funding Notes

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.
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