Division: Molecular and Clinical Medicine
Start Date: 20/09/21
This clinical training fellowship is truly translational with potential to immediately improve the clinical management of cancer patients through a precision medicine approach to drug dosing.
Many targeted anti-cancer drugs have been developed using maximal tolerated dose instead of pharmacological potency, leading to much higher doses than those predicted to be effective, causing unnecessary toxicity. Furthermore, these drugs are often potent inducers or inhibitors of the cytochrome P450 system responsible for the metabolism and disposition of almost all drugs. This can lead to adverse interactions with other anti-cancer therapies, or with drug combinations, which may be rendered ineffective or not tolerated. To improve cancer care, we need to do better than this ‘one-size fits all’ approach. We must measure drug exposure during treatment to ensure concentrations lie within the ‘therapeutic window’.
In a feasibility study (ADOPT 1), we have shown that a simple finger-prick blood spot test (BST) can be used to analyse plasma drug levels in cancer patients. Using a combination of BST drug-profiling, Mass Spec measurement of plasma drug levels and a unique P450 humanised mouse model (8HUM), the clinical fellow will address whether therapeutic drug monitoring will lead to improved tolerability and efficacy for anti-cancer therapies. The fellow will examine variability in drug exposure in cancer patients and evaluate how this relates to BMI, frailty, clinical outcomes and drug interactions. They will also study whether studies using 8HUM mice predict what is seen clinically.
Applicants to complete the Application form and email to [Email Address Removed] along with a CV and 2 academic references by Monday 22nd March 2021.
First class honours degree, and/or a Masters degree in a relevant discipline. (Non-clinical applicants)
MBChB (clinical applicants)
English language requirements
IELTS minimum overall score of 6.5
Reading 5.5, Listening 5.5, Speaking 5.5 Writing 6.0