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Adrenomedullin-2 receptor antagonists in T-cell lymphoma


Project Description

Cancer cells rely upon communication between themselves and to the host tissues to survive and grow. One hormone involved in cancer signalling is adrenomedullin (AM), which also has important physiological roles in the control of blood pressure. However there are two receptors for AM, and we have developed antagonist molecules that target the AM response in cancer while not affecting the physiological functions.
The project is to determine the importance of AM signalling in a rare cutaneous T-cell lymphoma, Sezary Syndrome, and will involve a range of techniques from assessment of receptor expression in Sezary cells and tissues, measurement of the effect of antagonists on signalling pathways, functional oncology assays in vitro, and finally in vivo studies using murine models of Sezary Syndrome.
This work has the potential to influence the choice of first clinical indication for trials of our small molecule antagonist, and will provide a training in a range of transferrable skills in a well-funded and enthusiastic group of academics, postdocs and students with a wide experience in successful supervision of PhD studies.

Funding Notes

Funding:
This is available as a self-funded project. In addition to fees and student living expenses, the work requires bench fee support of £12,000 p.a.

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. (add any additional requirements here)

Enquiries:
Professor Tim Skerry or Dr Gareth Richards ( or )

References

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select 'Oncology & Metabolism' as the department.

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