Advancements in the joint modelling of longitudinal and time-to-event data (advert reference: EE/DRFCEIS7/53631)
The joint modelling of longitudinal and time-to-event data has become a highly-active field of research over the last twenty years with recent focus on developing models to handle multiple longitudinal profiles along with several, potentially competing, time-to-event processes. Several situations remain in their infancy when it comes to methodological advances. Examples are the treatment of asynchronous longitudinal profiles, data encompassing multiple levels (i.e. patients within a hospital within a region), sample size and power calculations. There is also a need to develop models to handle longitudinal data in the form of counts, or percentages and improving flexibility in time-to-event models by incorporating barycentric rational interpolation in place of splines. Software to implement methods is also key in order to allow routine implementation of the most appropriate model for the data to hand. The focus of this project will be two-fold: developing novel models for situations not adequately dealt with in the current literature, encompassing ‘pre’ and ‘post’ data accumulation in the form of study design and methodological advances, and implementing these models in user-friendly R software to enhance dissemination.
Enquiries regarding this studentship should be made to: [Email Address Removed]
Applicants should hold a first or upper second class honours degree (in a relevant subject) from a British higher education institution, or equivalent. Students who are not UK/EU residents are eligible to apply, provided they hold the relevant academic qualifications, together with an IELTS score of at least 6.5.
To apply, e-mail [Email Address Removed] to request the appropriate application form, quoting the advert reference above. Alternatively, use the application link on this page.
Deadline for applications: 07 April 2014
Start Date: 1 October 2014
The studentship includes a full stipend, paid for three years at RCUK rates (in 2014/15 this is 13,863 pa) and Home/EU fees. Overseas candidates are also eligible to apply.
Wulfsohn MS, Tsiatis AA: A joint model for survival and longitudinal data measured with error. Biometrics 1997, 53:330-339.
Henderson R, Diggle P, Dobson A: Joint modelling of longitudinal measurements and event time data. Biostatistics 2000, 1(4):465-480.
Crowther MJ, Abrams KR, Lambert PC: Flexible parametric joint modelling of longitudinal and survival data. Stat Med 2012, 31(30):4456-4471.