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Age-appropriate dosage forms for pediatrics using novel digital manufacturing technology


   Institute of Pharmaceutical Science


About the Project

There has been a paradigm shift to solid dosage forms due to significant advantage including physical, chemical, and biological stability advantages. In comparison to liquid and semi-liquid formulations, solid dosage forms avoid the need for taste-masking or expensive packaging and delivery costs. It is of vital importance to provide a flexible solid dosage forms offer myriad of advantages for paediatrics, geriatrics, and patient-centered therapy. Formative manufacturing (via powder compression) is the established method for small- and large-scale production of tablets via wet and dry granulation or direct compression. Over the last few decades, conventional manufacturing methods in the pharmaceutical industry are geared for large batch production with large and expensive facilities, expert operators and multi-step production. The rigid nature and the high cost of the process make it unsuitable for specific dose personalisation. Tailoring the dose for one patient or a small number of patients is often achieved through the practice of tablet splitting/cutting of a ‘standard’ dose. However, such unsafe practice could result in variation of drug content and deliver a subtherapeutic or a supratherapeutic dose of API. In paediatrics, the modification of age-inappropriate formulations to achieve an intended dose is extensive and may lead to significant under- or over-dosing. Several novel digital manufacturing technologies such as additive manufacturing and powder deposition technologies have emerged as a promising method for on-demand manufacturing of personalised medication. This project aims to apply the latest development of digital manufacturing with a particular focus on age-appropriate dosage forms for paediatrics.

Person specification

We are looking to recruit ambitious and motivated graduates to address this ground-breaking research for fabrication and functionalisation of next generation oral delivery systems for proteins.

Research training

The project will involve using several techniques such as computer aided design (CAD), 3D printing technologies, physical characterization of solid dosage forms, essential formulation skills, Clinical research. The project will be carried out in collaboration with specialised paediatric clinical researcher.

Dr Alhnan has a leading expertise in pharmaceutical additive manufacturing https://kclpure.kcl.ac.uk/portal/alhnan.html   https://scholar.google.com/citations?user=boaKXLsAAAAJ&hl=en

Informal enquiries should be directed to Dr Mohamed A Alhnan:

Funding Notes

Applications are welcome year-round from Home/EU/Overseas self-funded students and applicants able to secure funding to cover all costs involved with PhD study, including living costs, tuition fees (and bench fees where required).

References

Research programme profile

https://www.kcl.ac.uk/study/postgraduate/research-courses/cancer-and-pharmaceutical-sciences-mphil-phd


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