About the Project
The aims of the PhD project are:
(i) To synthesise and biologically evaluate ALDH agonists and antagonists with potential to treat ocular, cancer and other diseases
(ii) To probe and/or investigate the expression of ALDHs in mono-layered and multilayered (spheroids) cancer cell lines, co-culture systems (e.g. cancer-associated fibroblasts), and clinical samples derived from cancer patients.
(iii) To investigate ALDH expression in (cancer) stem cells
(iv) To investigate the effect of ALDH-targeting inhibitors as single agents or in combination with targeted cancer therapies
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