Aligning chemokine receptor expression with monocyte/macrophage phenotype and function

Supervisors:
Prof Gerry Graham
Dr Stephen Jenkins

Project summary:
Macrophages are a key part of the innate immune system and are central players in antimicrobial responses. To achieve this they must navigate to infected sites and this process is regulated by chemokines and their receptors with which we have worked for over 30 years. Chemokine receptors are notoriously complex and precisely defining their role in macrophage biology has previously been difficult. We have generated unique in vivo models to help us to specifically address this issue giving us an international lead in this important research area. This project will specifically study the role for individual chemokine receptors in regulating macrophage dynamics in response to bacterial and viral infections. It will involve a combination of in vivo experimentation and transcriptomics with a view to assigning specific receptors to discrete macrophage functions. The student will receive training in in vivo biology, imaging and transcriptomic analysis and will be immersed in a world quality inflammatory biology environment.

This MRC programme is joint between the Universities of Edinburgh and Glasgow. You will be registered at the host institution of the primary supervisor detailed in your project selection.

All applications should be made via the University of Edinburgh, irrespective of project location via the link below.

http://www.ed.ac.uk/studying/postgraduate/degrees/index.php?r=site/view&id=919

Please note, you must apply to one of the projects and you must contact the primary supervisor prior to making your application. Additional information on the application process is available from the link above.

For more information about Precision Medicine and what is required when submitting an application, please visit:
https://www.gla.ac.uk/colleges/mvls/graduateschool/mrcdtpprecisionmedicine/