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Allosteric protein kinase inhibition - a new paradigm in Chemical Biology

   College of Medicine, Veterinary and Life Sciences

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  Prof A Tobin, Dr A Jamieson  No more applications being accepted  Funded PhD Project (UK Students Only)

Glasgow United Kingdom Biochemistry

About the Project


Prof Andrew Tobin

Dr Andrew Jamieson 

Project Summary:

The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium falciparum. We recently validated PfCLK3 as a drug target in malaria that offers prophylactic, transmission blocking, and curative potential (Science, 2019, 365, eaau1682). Orthosteric inhibitors of PfCLK3 have been identified and are being developed as a new class of antimalarial drug (J. Med. Chem., 2020, 63, 9300). The aim of this project is to develop molecular probes, derived from hit compounds identified from a DNA Encoded Library screen, that act as allosteric inhibitors of PfCLK3. We will use these probes to validate allosteric inhibition of PfCLK3 as a novel mechanism of action and to interrogate the biochemical function of PfCLK3.

Funding Notes

The studentship provides funding for tuition fees, a stipend and laboratory expenses for Home (UK) applicants only.
The MVLS/EPSRC grant provides tuition fees and stipend of at least £15,285 (UKRI rate 2020/21).
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