About the Project
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium falciparum. We recently validated PfCLK3 as a drug target in malaria that offers prophylactic, transmission blocking, and curative potential (Science, 2019, 365, eaau1682). Orthosteric inhibitors of PfCLK3 have been identified and are being developed as a new class of antimalarial drug (J. Med. Chem., 2020, 63, 9300). The aim of this project is to develop molecular probes, derived from hit compounds identified from a DNA Encoded Library screen, that act as allosteric inhibitors of PfCLK3. We will use these probes to validate allosteric inhibition of PfCLK3 as a novel mechanism of action and to interrogate the biochemical function of PfCLK3.
The MVLS/EPSRC grant provides tuition fees and stipend of at least £15,285 (UKRI rate 2020/21).
Please view application information here: https://www.gla.ac.uk/colleges/mvls/graduateschool/mvlsepsrcstudentships/
Once you have all the required application documentation, please apply here: https://www.gla.ac.uk/study/applyonline/?CAREER=PGR&PLAN_CODES=ZY38-7316
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.