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Alzheimer’s Society funded PhD studentship: how Alzheimer’s disease associated neuroinflammation is altered in Down Syndrome

  • Full or part time
  • Application Deadline
    Friday, February 07, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Applications are invited for a fully funded PhD studentship in the UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, to start 28th September 2020.

Dementia is the biggest health challenge of our century. The Dementia Research Institute (UK DRI - is the biggest UK initiative supporting research to fill this gap.

Research from the UK DRI at UCL ( will cover the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies to put to the test.


The Wiseman research group at the UK DRI at UCL are looking for a PhD student to join an Alzheimer’s Society funded project to understand how Alzheimer’s disease associated neuroinflammation is altered in Down Syndrome.

You will build hypotheses, design experiments and generate and analyse data to understand the early development of dementia in people with Down Syndrome, with a specific focus on neuroinflammation and changes to microglial biology; using both animal models and studies using human post-mortem brain material. You’ll interact and collaborate with other members of the Wiseman research group, the UK DRI and the wider national and international research communities to facilitate research breakthroughs in the areas of Trisomy21 and Alzheimer’s disease. Moreover, you will benefit from the advice and support of Alzheimer’s Society Network volunteers.


We are looking for a creative and proactive thinker who has an interest in understanding the molecular mechanisms that cause dementia in the context of Down syndrome. An interest in neuroscience and an undergraduate degree in the Life Sciences (2.1 or above) are required.

Informal enquiries

Please email Dr Frances Wiseman for further information about the project ().

Application procedures

Application is by CV and covering letter addressed to Dr Frances Wiseman and emailed to with the subject “Wiseman PhD”.

The successful applicant will then need to apply online to UCL by submitting the PhD application form via

Closing Date: 5pm, Friday 7 February 2020

Funding Notes

The studentship is funded by Alzheimer’s Society for three years including UCL tuition fee at home/EU rates and a stipend of £17,000 - £18,000 per year.

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