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An asymmetric synthesis of atropisomeric functionalised intermediates

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Atropisomers are stereoisomers that occur because of hindered rotation about a single bond, and this leads to two or more conformers that interconvert slowly enough to be isolated as single components. There are a large number of prominent natural products and pharmaceuticals that exhibit atropisomerism, however stereoselective synthetic methods towards these compounds are relatively rare. In this project, we will synthesise ortho-borylated biaryl atropisomers, and use chiral diols to promote a diastereoselective dynamic-thermodynamic resolution process. This method will deliver a novel class of chiral intermediates for further organic synthesis.

Funding Notes

This is a self-funded project.
If you have the correct qualifications and access to your own funding, either from your home country or your own finances, your application to work with this supervisor will be considered.
The applicant should have, or expect to gain, at least an upper second class degree or equivalent overseas qualification in a relevant subject.

References

For leading references see: J. Am. Chem. Soc., 2014, 136, 8642.

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