An asymmetric synthesis of atropisomeric functionalised intermediates

Atropisomers are stereoisomers that occur because of hindered rotation about a single bond, and this leads to two or more conformers that interconvert slowly enough to be isolated as single components. There are a large number of prominent natural products and pharmaceuticals that exhibit atropisomerism, however stereoselective synthetic methods towards these compounds are relatively rare. In this project, we will synthesise ortho-borylated biaryl atropisomers, and use chiral diols to promote a diastereoselective dynamic-thermodynamic resolution process. This method will deliver a novel class of chiral intermediates for further organic synthesis.