or
Continue with FacebookLooking to list your PhD opportunities? Log in here.
Dr Peter Ella-Tongwiis,
Prof Stephen Hughes,
Prof Iqbal Shergill
Applications accepted all year round
Self-Funded PhD Students Only
Wrexham
United Kingdom
Biochemistry
Cancer Biology
Cell Biology
Immunology
Microbiology
Molecular Biology
Medicine
Pathology
About the Project
The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. MAUMSS is located in Wrexham (North Wales, UK) and staffed by an interdisciplinary team of academics, clinicians, scientists and postgraduate students who are available to lead on and help other healthcare professionals develop and run all kinds of clinical research projects. It has several laboratories containing state-of-the-art molecular, analytical and diagnostic equipment. There are also meeting rooms, video-conferencing and hot-desk facilities too. All of this is available for use to encourage new researchers (promote lifelong learning and continuous professional development), help maximise research impact and ultimately provide better outcomes for patients and the public.
As part of its formal collaborative partnership with Wrexham University (WU), MAUMSS has been instrumental in conceiving, developing and subsequently delivering an Institute of Biomedical Science (IBMS) accredited BSc (Hons) Biomedical Science, an MSc Biomedical Science and two IBMS approved MRes programmes in Applied Biomedical Sciences Research and Applied Clinical Research. MAUMSS, in collaboration with WU, also deliver successful MPhil and PhD (including Professional Doctorates) programmes. To date, these academic programmes have been very successful and continue to grow and have provided the opportunity for the development of new academic programmes, which further strengthens the well-established collaborative partnership between BUCHB and WU.
PhD Project
Background:
Bladder Cancer remains a major health burden, with over 10,000 new cases diagnosed annually in the UK. Around 80% of all cases are diagnosed as Non-Muscle Invasive Bladder Cancer (NMIBC), and 75% of patients have cancer recurrence and progression within 10 years. Patients with NMIBC are treated by Trans-Urethral Resection of the Bladder Tumour (TURBT), with approximately 8% of patients subsequently developing post-operative complications, such as bleeding, pain and infection. Currently, there is limited literature on the 'normal' pathophysiological response to TURBT for NMIBC, and predictors for post-operative complications.
Aims:
The aim of this clinical-pilot observational study is to evaluate changes in routine and haemostatic blood tests following TURBT.
As part of your PhD you will be registered with Wrexham University (Wrexham, North Wales, UK) and based at BCUHB-MAUMSS.
NB: A small contribution toward tuition fees of up to £1500 per year may be provided for this study.
References
Ella-Tongwiis, P., Makanga, A., Shergill, I., & Fôn Hughes, S. (2021). Optimisation and validation of immunohistochemistry protocols for cancer research. Histology and histopathology, 36(4), 415–424. https://doi.org/10.14670/HH-18-317
Ella-Tongwiis, P., Lamb, R.M., Makanga, A. et al (2020). The role of antibody expression and their association with bladder cancer recurrence: a single-centre prospective clinical-pilot study in 35 patients. BMC Urol 20, 187. https://doi.org/10.1186/s12894-020-00759-3
Cancer Research UK. (2023). Bladder Cancer, Risks and Causes.
http://www.cancerresearchuk.org/about-cancer/bladder-cancer/risks-causes.
Burger, M., Catto, J.W., Dalbagni, G., Grossman, H.B., Herr, H., Karakiewicz, P., Kassouf,
W., Kiemeney, L.A., Vecchia, C.L., Shariat, S., & Lotan, Y. (2013) Epidemiology and Risk
Factors of Urothelial Bladder Cancer. European Association of Urology. 63(2):234-241.
DOI http://dx.doi.org/10.1016/j.eururo.2012.07.033.
Wells, H. (2015). Day case TURBT: the new UK gold standard? BAUS ePoster online
library. 99002.
Traxer, O., Pasqui, F., Gattegno, B., & Pearle, M.S. (2004). Technique and complications
of transurethral surgery for bladder tumours. British Journal of Urology International. 94(4): 492-496.
Ella-Tongwiis, P., Lamb, R.M., Makanga, A. et al (2020). The role of antibody expression and their association with bladder cancer recurrence: a single-centre prospective clinical-pilot study in 35 patients. BMC Urol 20, 187. https://doi.org/10.1186/s12894-020-00759-3
Cancer Research UK. (2023). Bladder Cancer, Risks and Causes.
http://www.cancerresearchuk.org/about-cancer/bladder-cancer/risks-causes.
Burger, M., Catto, J.W., Dalbagni, G., Grossman, H.B., Herr, H., Karakiewicz, P., Kassouf,
W., Kiemeney, L.A., Vecchia, C.L., Shariat, S., & Lotan, Y. (2013) Epidemiology and Risk
Factors of Urothelial Bladder Cancer. European Association of Urology. 63(2):234-241.
DOI http://dx.doi.org/10.1016/j.eururo.2012.07.033.
Wells, H. (2015). Day case TURBT: the new UK gold standard? BAUS ePoster online
library. 99002.
Traxer, O., Pasqui, F., Gattegno, B., & Pearle, M.S. (2004). Technique and complications
of transurethral surgery for bladder tumours. British Journal of Urology International. 94(4): 492-496.
Register your interest for this project
The university will respond to you directly. You will have a FindAPhD account to view your sent enquiries and receive email alerts with new PhD opportunities and guidance to help you choose the right programme.
It looks like you alredy have a FindAPhD Account
Log in to save time sending your enquiry and view previously sent enquiries
* required field
The information you submit to Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.
Search suggestions
Based on your current searches we recommend the following search filters.
Check out our other PhDs in Wrexham, United Kingdom
Start a New search with our database of over 4,000 PhDs
PhD suggestions
Based on your current search criteria we thought you might be interested in these.
Investigating the efficacy of urine, tissue and blood-based biomarkers for the detection of non-muscle invasive bladder cancer (recurrence/progression)
Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS)
Model-based health economic evaluation of interventions for improving primary healthcare for patients with non-communicable diseases (NCDs) during severe flooding in India
University of Birmingham
Investigating the impact of different flooring surfaces on EMG muscle activation of the knee and hip muscles during squatting and stair descending in patients with Patellofemoral Pain.
University of Worcester
