About the Project
Hypothesis: It was originally hypothesised that CGIs at developmentally-regulated genes may be relics of ancestral CGIs differentially maintained during evolution (3). However, only the well-studied α-globin locus has provided a good example supporting this hypothesis: the human α-globin genes are associated with a CGI which appears to have been lost in rodents during evolution (2). The presence of a CGI in human therefore has an important implication for the epigenetic regulation of this locus. Comprehensive genomic studies spanning a broad variety of species are therefore needed to validate this hypothesis.
Aim: To study the genomic sequences recruiting PcG across species and investigate their role in epigenetic regulation of their target genes. The availability of numerous reference genomes will enable the study of these sequences across major taxa. This study will provide an unprecedented evolutionary model of gene regulation across species.
This opportunity is open to UK and international students and provides funding to cover stipend, tuition fees and consumable/travel costs. Applications including a statement of interest and full CV with names and addresses (including email addresses) of two academic referees, should be emailed to [Email Address Removed].
When applying for the studentship please state clearly the project title/s and the supervisor/s in your covering letter.
Other projects available:
We would encourage applicants to list up to three projects of interest (ranked 1st, 2nd and 3rd choice) from those listed with a closing date of 10th January 2021 at https://www.ed.ac.uk/roslin/work-study/postgraduate/studentships
2. Lynch, M.D., Smith, A.J., De Gobbi, M., Flenley, M., Hughes, J.R., Vernimmen, D., Ayyub, H., Sharpe, J.A., Sloane-Stanley, J.A., Sutherland, L. et al. (2012) An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J.
3. Antequera, F. (2003) Structure, function and evolution of CpG island promoters. Cellular and molecular life sciences : CMLS, 60, 1647-1658.
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