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An Investigation into the Identification, Validation and Biological Understanding of Biomarkers Post-Spinal Cord Injury

   School of Pharmacy and Bioengineering

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  Dr K Wright  No more applications being accepted  Funded PhD Project (European/UK Students Only)

About the Project

Neurological recovery following spinal cord injury (SCI) can be highly variable. The pathophysiology underpinning this variability is not currently well understood. Identifying biomarkers of recovery will provide an avenue of research to begin unravelling these mechanisms. Highly predictive biomarkers would also provide great value to the development of novel therapies for SCI, as the variability of outcomes currently makes adequately powering clinical trials challenging. The focus of this project is to develop a prognostic biomarker panel for SCI and co-morbidities such as pressure sores to enhance our understanding of the mechanisms involved in the pathology of the disorder and in order to identify new targets with potential for restoration of function. Previous work in our lab modelling neurological outcomes of SCI with routinely measured haematological markers found markers associated with inflammation and liver function. In this PhD study we aim to evaluate the proteome and metabolome of SCI plasma, serum, pressure sore fluid and urine, and validate prognostic models of SCI outcomes via routine heamotology with a large dataset from a collaborating site. The primary objectives of this study are to: (i) Validate prognostic models with external datasets; (ii) Utilise proteomics and/or metabolomics to further elucidate the underlying biochemistry associated with SCI recovery. This project provides the opportunity to work closely with industry, clinicians and human patient samples/data to address a pertinent clinical question that will likely lead to patient benefit. The studentship will be based at the RJAH Orthopaedic Hospital in Oswestry, however, there will be the occasional need to attend training at Keele University.

For any further information or for an informal chat about the project please contact: Dr Karina Wright on [Email Address Removed]

Funding Notes

There is no stipend for this project but funding is available to cover 100% UK/EU student tuition fees and consumables for 3 years.
Non-UK/EU applicants will be considered if they are able to self-fund any additional tuition fee costs that may exist and can obtain a visa to study in the UK.
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