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Anglia Ruskin University ARU Featured PhD Programmes
Anglia Ruskin University ARU Featured PhD Programmes

An understanding of the factors critical for successful paternal genome remodeling


research

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Dr Helena Fulkova No more applications being accepted Funded PhD Project (Students Worldwide)
Prague Czech Republic Cell Biology Developmental Biology Genetics Human Genetics Reproductive Biology

About the Project

Department of Cell Nucleus Plasticity: http://www.iem.cas.cz/en/research/departments/department-of-cell-nucleus-plasticity/

The emergence of the nucleus is a major evolutionary event that discriminated eukaryotes from prokaryotes. It is a hallmark of nearly all eukaryotic cells and central to their function. Aberrations in the nuclear composition and structure are linked to diseases such as cancer. The project is focused on how cells build a nucleus from different genomic substrates and what is the consequence of nuclear dysregulation; with the ultimate goal of elucidating the function of the nucleus as an essential cellular structure. While many theories exist, it is extremely difficult to assess these in tissue culture cells. Early embryos offer a unique opportunity to study these phenomena: Oocytes build a nucleus from a practically naked DNA (sperm), and also two morphologically and functionally different nuclei (maternal and paternal) co-exist in a common cytoplasm after fertilization. In contrast to egg extracts, this system offers an unprecedented chance to rigorously test the consequence of targeted nuclear dysregulation through the ability of embryos to give rise to live animals.

The successful candidate should:

- be a highly motivated student looking to work in a dynamic and competitive environment

 desirably have a background in molecular biology, biochemistry methods, reproductive or developmental biology and/or micromanipulations.

- ideally have a good background in microscopy and epigenetics

- be strongly motivated to learn, adapt and develop new methods.

- be happy to work with animals (mice) and animal material, as this is a requirement of the position

- have good English skills, as an exchange of students/staff with Japanese laboratories throughout the project will be required (strong work ethics desirable)

How to apply: www.iem.cas.cz/phd

If you are interested, please visit the official website and submit the simple online application form. You can apply for up to 3 PhD positions. We are looking forward to hearing from you!


Funding Notes

After admission to the graduate program, the student usually receives an academic fellowship. In addition, the student becomes an IEM CAS employee and receives a salary (including payments towards social and healthcare insurance) and other benefits. This is financed by internal and grant funds of the IEM CAS.

References

Dissecting the role of the germinal vesicle nuclear envelope and soluble content in the process of somatic cell remodeling and reprogramming. J Reprod Dev. 2019 Oct 23;65(5):433-441.
The nucleolus-like and precursor bodies of mammalian oocytes and embryos and their possible role in post-fertilization centromere remodeling. Biochem Soc Trans. 2020 Apr 29;48(2):581-593. doi: 10.1042/BST20190847.
The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition. Development. 2014 Apr;141(8):1694-704.
The maternal nucleolus is essential for early embryonic development in mammals. Science. 2008 Feb 1;319(5863):613-6.
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