Department of Cell Nucleus Plasticity: http://www.iem.cas.cz/en/research/departments/department-of-cell-nucleus-plasticity/
The emergence of the nucleus is a major evolutionary event that discriminated eukaryotes from prokaryotes. It is a hallmark of nearly all eukaryotic cells and central to their function. Aberrations in the nuclear composition and structure are linked to diseases such as cancer. The project is focused on how cells build a nucleus from different genomic substrates and what is the consequence of nuclear dysregulation; with the ultimate goal of elucidating the function of the nucleus as an essential cellular structure. While many theories exist, it is extremely difficult to assess these in tissue culture cells. Early embryos offer a unique opportunity to study these phenomena: Oocytes build a nucleus from a practically naked DNA (sperm), and also two morphologically and functionally different nuclei (maternal and paternal) co-exist in a common cytoplasm after fertilization. In contrast to egg extracts, this system offers an unprecedented chance to rigorously test the consequence of targeted nuclear dysregulation through the ability of embryos to give rise to live animals.
The successful candidate should:
- be a highly motivated student looking to work in a dynamic and competitive environment
desirably have a background in molecular biology, biochemistry methods, reproductive or developmental biology and/or micromanipulations.
- ideally have a good background in microscopy and epigenetics
- be strongly motivated to learn, adapt and develop new methods.
- be happy to work with animals (mice) and animal material, as this is a requirement of the position
- have good English skills, as an exchange of students/staff with Japanese laboratories throughout the project will be required (strong work ethics desirable)
How to apply: www.iem.cas.cz/phd
If you are interested, please visit the official website and submit the simple online application form. You can apply for up to 3 PhD positions. We are looking forward to hearing from you!
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