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Analysis of mRNA therapeutics

  • Full or part time
  • Application Deadline
    Wednesday, January 29, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

In vitro transcribed messenger RNA (mRNA)-based therapy for de novo protein expression in cells is a new important therapeutic. This method enables desired proteins to be produced in cells by delivery of the mRNA, which does not integrate into the host genome and results in transient production of target proteins. Therapeutic applications of in vitro transcribed mRNA include cellular reprogramming, stem cell engineering, and protein replacement therapy.

Significant challenges remain in the characterisation of synthesised mRNA therapeutics. The aim of this project is to develop novel analytic methods to purify and characterise mRNA therapeutics generated using in vitro transcription. Mass spectrometry and high-performance liquid chromatography methods will be developed to analyse this emerging important therapeutic.
The successful candidate will receive training in HPLC, mass spectrometry, molecular biology, in vitro transcription, design and analysis of experimental data. The project would suit bioscience/chemistry graduates with a strong interest in analytical science and biotechnology.

Biological engineering is one of the fastest-growing employment sectors and many of our Ph.D. graduates have found employment in the analytical field through to research and development in biotechnology/biopharmaceutical industries.

The student will join a well-established research group with access to analytical facilities that contain state of the art mass spectrometry and high-performance liquid chromatography instruments. Training will be provided by experienced researchers for the hands-on operation of all analytical equipment in the facility.

Funding Notes

Applicants should have a First Class or high Upper Second Class Honours degree in chemistry, bioscience biological engineering, biotechnology or related degree with a strong interest in analytical science. If English is not your first language then you must have an International English Language Testing Service (IELTS) average of 6.5 or above with at least 6.0 in each component. Please contact Prof Mark Dickman via [email protected] .ac.uk if you are interested in this project.

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