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Analysis of soft matter gels during dissolution of solid oral pharmaceutical products by magic angle spinning NMR spectroscopy


   Warwick Centre for Doctoral Training in Analytical Science

   Applications accepted all year round  Funded PhD Project (UK Students Only)

About the Project

Supervisors: Steven Brown (Physics), Maria Adobes Vidal (Novartis)

Reliable drug release or dissolution from solid oral dosage forms is paramount to deliver consistent quality and therapeutic efficacy. The drug release is a complex, multistep process, wherein the formation of a gel-like barrier at the solid-liquid interface is a frequently observed challenge that impacts the desired drug release behavior/performance. This results in laborious formulation optimization cycles, inadequate formulation designs and suboptimal analytical quality control.

A key question for adequate formulation design is the role of molecular interactions in gel formation. In this project, you will develop solid-state NMR methods that make use of state-of-the-art magic-angle spinning (MAS) technology to characterize the gelling phenomenon in pharmaceutical formulations. Understanding the structure and dynamics of gel formation at atomic level will enable a rapid response to formulations challenges and promote the development of novel pharmaceutical products to improve people´s life.

Start date: Monday, 26 September 2022

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