About the Project
The project will involve aseptic processing of human blood samples and cell lines, cell isolation and sorting and high level flow cytometric analyses. Immunological functional assays including target cell conjugation and lysis, cytokine secretion and cell proliferation by flow cytometry, ELISA and immunofluorescence microscopy/confocal will be essential techniques. RNA extraction and gene profiling techniques will be used to identify target pathways which will be blocked to determine their roles in the NK lytic process.
The applicant will help to establish a murine model of human NK cells using an immunodeficient mouse strain which is transgenic for human IL-15. This strain will be used to validate the in vitro findings in vivo.
More detailed information about the research project is available on request from the principal supervisor: [email protected]
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