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Analytical and computational chemical approaches to explore marine terpenoid chemo-diversity and discover novel natural products


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  Dr Shane O'Reilly, Dr Nicolas Touzet, Dr B Kelleher, Dr Marco Garcia  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Marine natural products have provided significant benefits for humanity and are fundamental if we are to create an innovative, sustainable marine sector for future generations - the ‘blue bioeconomy’. Terpenoids are isoprene-based molecules that comprise the most diverse natural products known and have important biological and ecological roles. Terpenoid discovery has also led to revolutionary blockbuster anticancer drugs, cosmetic products and products for many other commercial applications. Despite this promise, marine terpenoids have received little focus from a bioprospecting perspective. Together with advances in modern chemical, culture-independent biological and computational tools, there is a significant opportunity for accelerated discovery of high-value marine terpenoids with broad commercial potential. The recruited PhD student will investigate the diversity of terpenoids from terpenoids from seaweeds, sponges and their associated microorganisms from Irish waters using advanced chemical (mass spectrometry and nuclear magnetic resonance) and cheminformatic tools to explore the diversity of novel terpenoids, predict their bioactivity and isolate and elucidate structures of target terpenoids.

PROFILE REQUIREMENTS: Motivated candidates with strong interests in organic, analytical and natural product chemistry. The candidate must have at least a 2.1 honours B.Sc. (essential) and/or a M.Sc. (desirable) in chemistry, analytical science, biochemistry or related disciplines. Candidates with substantial experience in mass spectrometry instrumentation and data analysis, lipid (bio)chemistry and computational chemistry will be considered favourably. The candidate must be fluent in English with excellent oral and written communication skills.

closing date 5pm on 21st of August application to [Email Address Removed]

Funding Notes

FELLOWSHIP STIPEND: €16,000 yearly (€3,000 of this is for college fees)
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