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Ancient genomics of sheep, domestic animal mobility and Bronze Age migrations.


Smurfit Institute of Genetics

Monday, May 31, 2021 Funded PhD Project (European/UK Students Only)

About the Project

A four-year PhD studentship is available in the Genetics Dept, Trinity College Dublin, to study the ancient genomics of sheep. The third Millennium BC was a period of extreme flux in Europe, with massive inward human migrations from the Eurasian Steppe. Whether ancient animal genomes accompanied these movements of pastoralists and how they effected livestock economies are open questions. For example, will we find the genomic signatures of woolly sheep emerging, potentially transforming clothing and other textiles for ancient Europeans? The student will engage with aDNA techniques, high throughput sequencing and data analysis.  As well as inference about the past, livestock genomics will inform on production traits in modern breeds. The student will work as part of a team investigating a wider ERC-funded project (AncestralWeave) on ancient cattle, sheep and goat genomics and will involve interaction with archaeological collaborators. Supervision will be by Prof Dan Bradley There will be the opportunity to attend selected international courses and conferences during the project. A background in bioinformatics or mathematical aspects of genetics is a benefit but not a requirement for candidates. The Dept Genetics, TCD, has an outstanding record of PhD supervision and the host lab has an international reputation in ancient livestock and human genetics (see example references below


References

1. Cassidy LM, Ó Maoldúin R, Kador T, Lynch A, Jones C, Woodman PC, Murphy E, Ramsey G, Dowd M, Noonan A, Campbell C, Jones ER, Mattiangeli V and. Bradley DG (2020) A dynastic elite in monumental Neolithic society. Nature 582: 385-388.
2. Verdugo MP, Mullin VE, Scheu A, Mattiangeli V, Daly KG, Maisano Delser P, Hare AJ, Burger J, Collins MJ, Kehati R, Hesse P, Fulton D, Sauer EW, Mohaseb FA, Davoudi H, Khazaeli R, Lhuillier J, Rapin C, Ebrahimi S, Khasanov M, Vahidi SMF, MacHugh DE, Ertuğrul O, Koukouli-Chrysanthaki C, Sampson A, Kazantzis George, Kontopoulos I, Bulatovic J, Stojanović I, Mikdad A, Benecke N, Linstädter J, Sablin M, Bendrey R, Gourichon L, Arbuckle BS, Mashkour M, Orton D, Kolska Horwitz L, Teasdale MD, Bradley DG. (2019) Ancient cattle genomics, origins and rapid turnover in the Fertile Crescent. Science 365: 173-176.
3. Daly KG, Delser PM, Mullin VE, Scheu A, Mattiangeli V, Teasdale MD, Hare AJ, Burger J, Verdugo MP, Collins MJ, Kehati R, Erek CM, Bar-Oz G, Pompanon F, Cumer T, Çakırlar C, Mohaseb AF, Decruyenaere D, Davoudi H, Çevik, Ö, Rollefson G, Vigne, J-D, Khazaeli R, Fathi H, Doost SB, Rahimi Sorkhani R, Vahdati AA, Sauer, EW, Azizi Kharanaghi H, Maziar S, Gasparian B, Pinhasi R, Martin L, Orton D, Arbuckle BS, Benecke N, Manica A, Kolska Horwitz L, Mashkour M, Bradley DG (2018) Ancient goat genomes reveal mosaic domestication in the Fertile Crescent. Science 361: 85-88.

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