About the Project
Hypothesis: Nano-encapsulated ITCs possess enhanced anti-angiogenetic, and anti-tumor activities.
There are 3 main objectives:
(i) to determine the effectiveness of selected ITCs on cell proliferation, apoptosis and autophagy.
(ii) to compare the bioactivity of nano encapsulated ITCs with non-encapsulated form on angiogenesis using 3D co-culture of HUVECs and pericytes.
(iii) to study the mechanisms of action.
For more information on the supervisor for this project, please go here: https://people.uea.ac.uk/y_bao
This is a PhD programme.
The start date of the project is October 2020.
The mode of study is full-time. The studentship length is 4 years (3 years period of study, 1 year period of registration).
Acceptable first degree in subject areas including Biochemistry, Cell/Molecular Biology, Cancer Biology/Oncology, and Nutrition.
The standard minimum entry requirement is 2:1.
A bench fee may also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.
(2) Liu P, Atkinson SJ, Akbareian SE, Zhou Z, Munsterberg A, Robinson SD, Bao Y. Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. Sci Rep. 2017; 7(1):12651.
(3) Liu P, Behray M, Wang Q, Wang W, Zhou Z, Chao Y, Bao Y. Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots. Sci Rep. 2018;8(1):1084.
(4) Wang Q, Alshaker H, Böhler T, Srivats S, Chao Y, Cooper C, Pchejetski D. Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer. Sci Rep. 2017;7(1):5901. doi:10.1038/s41598-017-06142-x.
(5) Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi Y, Qi S, Bao Y, Nie G. Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS Nano, 2019; DOI: 10.1021/acsnano.9b07032.
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