Antimicrobial Resistance: hijacking bacterial signal transduction pathways to increase antibiotic uptake
Supervisor: Dr Seung Lee
Co-supervisor Dr Nicholas D. Evans, Dr Tracey Newman
A fully-funded 3 year PhD studentship (Institute for Life Sciences studentship) in chemical biology and medicinal chemistry at the University of Southampton is available. The project will pioneer a novel strategy to tackle antimicrobial resistance through the small molecule approach.
Multidrug resistant (MDR) pathogens are among the top threats to global public health, which have evolved to resist any conventional antibiotics. Many efforts are being made to overcome these problems, and our approach is to utilise a novel drug influx mechanism of bacteria. Based on the fundamental understanding of the signalling system that triggers the expression of a drug influx channel, we aim to develop activators of this signalling pathway. This is a totally new concept of an antibiotic approach in contrast to traditional inhibitory strategies. We will discover and optimise these carbohydrate based small molecule activators of an antibiotic. This accelerated influx of drug molecules will overwhelm the efflux or modification of drugs by bacteria, eventually overturning the resistance. In addition, we will devise a further strategy of delivering this molecule inside infected macrophages, targeting dormant pathogens. Thus, the project will establish resistance breakers and antibiotic potentiators.
You will design, synthesise and test biologically small molecules that activate the drug influx channel. At a certain point, you will also be involved in the development of a drug carrier for macrophage delivery. This interdisciplinary project will be performed in Chemistry in the first place, and as the project is going on, you will need to spend some time in Engineering and Medicine.
The studentship provides fees and stipends on a UKRI scale for three years, and welcomes applicants from UK and EU. We particularly encourage applicants with background of chemistry who are interested in chemical biology, organic chemistry and/or medicinal chemistry.
If you wish to discuss any details of the project informally, please contact Seung Lee, School of Chemistry, Email: [Email Address Removed], Tel: +44 (0) 2380 592987.
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).
Closing date: applications should be received no later than 31 March 2020 for standard admissions, but later applications may be considered depending on the funds remaining in place.
Funding: full tuition for EU/UK Students plus, for UK students, an enhanced stipend of £15,009 tax-free per annum for up to 3 years.
How To Apply
Applications should be made online here selecting “PhD Chemistry (Full time)” as the programme. Please enter Seung Lee under the Proposed Supervisor.
Applications should include:
Two reference letters
Degree Transcripts to date
Apply online: https://www.southampton.ac.uk/courses/how-to-apply/postgraduate-applications.page
For further information please contact: [Email Address Removed]
Equality, Diversity and Inclusion is central to the ethos in Chemistry. In recognition of our continued commitment to improving equality for women in science we were awarded an Athena SWAN Silver award in 2014 a and a second Silver award in 2017. Chemistry gives full consideration to applicants that wish to work flexibly including part-time and due consideration will be given to applicants who have taken a career break. The University has a generous maternity policy*, onsite childcare facilities. For further information please visit https://www.southampton.ac.uk/chemistry/about/Equality/index.page
How good is research at University of Southampton in Chemistry?
FTE Category A staff submitted: 44.80
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