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Antimicrobial resistance mechanisms and their regulation in a Gram-negative pathogen

Department of Infection, Immunity and Cardiovascular Disease

About the Project

Antimicrobial resistance is an extremely serious and ever increasing problem. The increasing prevalence of antibiotic-resistant bacteria is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050. The problem is compounded by the absence of new classes of antibiotics to treat bacterial infections in recent years. One group of bacteria that are notorious for their inherent resistance to a wide variety of antibiotics are the Burkholderia. This genus includes a number of opportunistic pathogens, such as B. cenocepacia, that are difficult to eradicate following the establishment of an infection.

The aim of this project is to analyse the antibiotic resistance mechanisms of Burkholderia cenocepacia in more detail. This organism is highly resistant to β-lactams and aminoglycosides. Therefore, exploring the resistance to these two groups of antibiotics will be a priority. The project will also seek to investigate the regulatory mechanisms that are responsible for activating the expression of antibiotic-resistance genes.

Funding Notes

Open to Home/EU and Overseas students that have secured funding for their studies.

Candidates must have a first or upper second class honours degree or equivalent.

Interested candidates should in the first instance contact Dr Mark Thomas

How to apply
Please complete a University Postgraduate Research Application form available here View Website

Please clearly state the prospective main supervisor in the respective box and select ‘Infection, Immunity and Cardiovascular Disease’ as the department.

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