About the Project
The aim of this proposal is to apply the latest analytical advances to develop and employ new assays to study health and disease. The programme will employ a range of techniques including LC-MS/MS, ICP-MS and 400 & 600 MHz NMr spectroscopy.
Using this approach, novel assays will be developed to study aspects of diet, health, disease and/or drug use. The project will build on a number of successful strands of research conducted over the past two decades.
These include the a number of key recent findings:-
(i) the first assay for social drug use and doping based on hair analysis for >200 drugs or their metabolites [Ref 1],
(ii) the first assay capable of accurate measurement of 10 forms of vitamin D which allowed full study of the vitamin D metabolome for the first time [Ref 2],
(iii) the first demonstration of the interaction of foodstuffs with testosterone metabolism [Ref 3],
(iv) the potential inhibitory effects of drugs on steroid metabolism and also herbal medicine-drug interactions [Ref 4 & 5].
Further details, please see the references below along with the descriptions on my staff web page at:
2. Shah, Iltaf, et al. (2014) Exploring the role of vitamin D in type 1 diabetes, rheumatoid arthritis and Alzheimer's disease: new insights from accurate analysis of ten forms. The Journal of Clinical Endocrinology & Metabolism, 99(3).
3. Jenkinson, Carl, et al. (2012) Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. Steroids, 77(6), pp. 691-695.
4. Zachar, Gergely, et al. (2017) Inhibitory effects of diclofenac on steroid glucuronidation in vivo do not affect hair-based doping tests for stanozolol. Molecules, 22(6), p. 976.
5. Picking, David, et al (2018) Inhibition of cytochrome P450 activities by extracts of 'Hyptis verticillata' Jacq. : Assessment for potential HERB-drug interactions. Molecules, 23(2), 430.
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.