Incorporation of metals such as Hg(II) and Ag(I) into DNA leads to novel base pairs. They fit in canonical DNA duplex, and the metal array is shielded from the solvent. Moreover, the metals chained along the helical axis provide an optimal electronic pathway, suitable for enhanced charge transport. The project is aimed at theoretical modeling of physicochemical properties of various metallo-DNAs including and optimization of the functional molecules as particular nanoelectronic devices. The research is conducted in close collaboration with domestic and Japanese laboratories.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
Tanaka Y., et al. Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and other metallo-base-pairs” Chem. Commun., 51, (2015), pp 17343-17360.
Dairaku T., Furuita K., Sato H., Sebera J., Nakashima K., Ono A., Sychrovsky V., Kojima C., Tanaka Y., “Hg-II/Ag-I-mediated base pairs and their NMR spectroscopic studies”, Inorg. Chim. Acta, 452, (2016), pp 34-42.