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Application of molecular imprinted polymer nanoparticles for surface proteomics


Project Description

Surface proteins are very important targets for diagnostic and therapeutic applications as they participate in major cellular functions and inter-cellular communication. Here we propose an innovative approach for discovery of molecular markers on cancer cells surface using molecular imprinting. This technique will allow stratification of different cell lines and tissue samples by prognostic markers, assist with understanding of pathogenetic mechanisms and help with identification of antigenic sequences (‘epitopes’), paramount for production of antibodies and development of synthetic receptors. The proposed approach will advance fundamental research in surface proteomics
and provide an effective tool for diagnostics and personalised medicine.

Entry requirements

Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The University of Leicester English language requirements apply where applicable.

How to apply

The online application and supporting documents are due by Thursday 25th April 2019.

Any applications submitted after the deadline will not be accepted for the studentship scheme.

References should arrive no later than Monday 29th April 2019.

Applicants are advised to apply well in advance of the deadline, so that we can let you know if anything is missing from your application.

Required Materials:

1. Online application form
2. Two academic references
3. Transcripts
4. Degree certificate/s (if awarded)
5. Curriculum Vitae
6. English language qualification

Applications which are not complete by the deadline will not be considered for the studentship scheme. It is the responsibility of the applicant to ensure the application form and documents are received by the relevant deadlines.

All applications must be submitted online, along with the supporting documents as per the instructions on the website.

Please ensure that all email addresses, for yourself and your referees, are correct on the application form.

Project / Funding Enquiries

Application enquiries to
Closing date for applications – 25th April 2019

Funding Notes

This research project is one of a number of projects in the Department. It is in competition for funding with one or more of these projects. Usually the project which receives the best applicant will be awarded the funding.

Home/EU Applicants

This project is eligible for a fully funded Graduate Teaching Assistant studentship which includes :

• A full UK/EU fee waiver for 4 years
• A stipend/salary package at UKRI rates

International Applicants:

This project does not have any funding for international students.

References

1. Compton CC. Colorectal carcinoma: Diagnostic, prognostic, and molecular features. Mod. Pathol. 2003;16:376–388.
2. Chute JP, Chen T, Feigal E, Simon R, Johnson BE: Twenty years of phase III trials for patients with extensive-stage small-cell lung cancer: perceptive progress. J Clin Oncol. 1999, 17: 1794-1801.
3. Canfarotta F., Poma A., Guerreiro A., Piletsky S. (2016). Solid-phase synthesis of molecularly imprinted nanoparticles (MIP NPs) for diagnostic applications. Nature Protocols, 11, 443-455.
4. Piletsky S., Piletska E., Canfarotta F., Karim K., Jones D., Norman R., Guerreiro A. Methods and kits for determining binding sites. GB1704823.2.

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