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Artificial blood

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Inspired by Nature, we have developed a number of macromolecules that can bind a release oxygen. These have included polyfluorinated micelles, polyion complexes and porphyrin cored polymers. All of these molecules have the potential to be applied as a plastic or artificial blood product. This work has been featured at the Science museum in London and appeared in a number of newspapers articles, radio programmes and television documentaries around the world (i.e. http://news.bbc.co.uk/1/hi/england/north_yorkshire/6645923.stm). This project aims to develop larger water-based systems that can be used in accident or emergency situations. Specifically, the aim is to use these molecules as alternative “volume expanders” that can also bind and release oxygen (i.e. for use as an oxygen delivering plasma). We also propose to encapsulate these new molecules within very large self-assembled micellar or vesicle system. In doing so, the self-assembled systems will resemble the size, shape and functionality of a blood cell. Once constructed and assembled, studies to measure oxygen stability and reversible oxygen binding will be undertaken.

Funding Notes

This is a self-funded project. The applicant should have or expect to gain at least an upper second class degree, or equivalent overseas qualification, in a relevant subject.

If you have the correct qualifications and access to your own funding, either from your home country or your own finances, your application to work with this supervisor will be considered.

References

Key references
1. Fan M, Alghassab TS & Twyman LJ; Increased Oxygen Solubility in Aqueous Media Using PEG–Poly-2,2,2-trifluoroethyl Methacrylate Copolymer Micelles and Their Potential Application as Volume Expanders and as an Artificial Blood Product. ACS Applied Bio Materials, 2018, 1(3), 708-713.
2. Twyman LJ & Ge Y; Porphyrin cored hyperbranched polymers as heme protein models. Chem. Comm. 2006, (15), 1658-1660

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