Artificial Cells with Biochemical Clocks: Development of Computational Models

Artificial cells are engineered materials that mimic one or more of the functions of living biological cells. Oscillating chemical processes are common within living organisms to control a variety of essential processes, including the metabolism of sugars and the release of hormones. To better understand oscillatory biochemical processes and to utilise them in artificial cell technologies, minimal systems of biochemical oscillations must be developed.

In this project you will build computational models of artificial cells consisting of hollow vesicle capsules encapsulating enzymes. You will systematically investigate how the different properties of the artificial cells affect the chemical processes taking place. The research will involve developing code in C++ or alternative programming language, combining chemical reaction in nano-sized compartments with transport processes such as diffusion and convection.

This work will provide valuable new insights into the coupling between confinement, communication and feedback processes in living organisms and develop the groundwork for application of oscillatory systems for novel advances in biotechnology and materials science. The project will provide ample opportunity for student-led initiative and innovation in this exciting multidisciplinary field.

This fully funded 4-year computational modelling PhD will work in close collaboration with the experimental PhD project at the University of Leeds as part of a broader Leverhulme Trust funded research project. This is an ideal project for a student with a passion for interdisciplinary science and computational modelling at the interface of soft matter and biomolecular sciences.

For further enquiries please contact Professor Annette Taylor on email [Email Address Removed].