Artificial metalloenzymes for catalysing new-to-nature reactions

In the Rhys lab we design and engineer peptides and proteins for new applications. For this project we are looking for a PhD student who is interested in developing new enzymes to catalyse reactions that are not known to occur in nature. We will achieve this by designing and optimising Artificial Metalloenzymes (ArMs). ArMs are proteins that contain non-natural metal complexes. In this project we will synthesise transition-metal complexes that will be bound to highly stable proteins and explore cross-coupling reactions. Using these ArMs we will develop environmentally friendly alternatives to existing cross-coupling reactions, by catalysing reactions in water at near-ambient temperature using more earth-abundant metals.

It's an exciting time to research ArMs because you will be joining a global community of scientists that is rapidly growing. During your PhD there will be opportunities for you to present your work at national and international conferences.

This project is ideally suited for anyone with a background in synthetic inorganic/organic chemistry or molecular biology and is looking to expand and develop their skills further. It is a highly interdisciplinary project where you will have the opportunity to develop skills in synthetic chemistry, chemical biology, molecular biology, structural biology, protein design and computational modelling. These are very desirable research skills that, upon completing your PhD, will make you suitable for a wide range of opportunities in academia or industry.

The Rhys lab is a supportive environment that cares about the development of its students and staff. We encourage you to apply regardless of age, disability, ethnicity, gender and sexual orientation. We are open to anyone looking to contribute to making the lab a diverse, inclusive and friendly environment.

For more information visit www.rhyslab.com

Academic criteria

Suitable applicants should hold a first class degree or a good 2.1 and/or an appropriate Master’s level qualification (or their equivalent) in Chemistry, Biochemistry or similar subjects.

English Language

Applicants whose first language is not English will be required to demonstrate proficiency in the English language (IELTS 6.5 or equivalent)  English language requirements for postgraduate students - Study - Cardiff University

Supervisor:

Dr Guto Rhys - Guto.rhys@uni-bayreuth.de

Dr Rhys will be joining Cardiff University later this year.

Application

Application deadline Friday 19th August 2022

We reserve the right to close this post early if sufficient applications are received. Early application is advised.

If you wish to have an informal chat with the supervisor about this project, please feel free to contact them directly.

To apply please follow the link and apply for a Chemistry PhD

Chemistry - Study - Cardiff University

Start date options - 1^st October 2022 or 1^st January 2023

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive environment for all. We welcome applications from all members of the global community irrespective of age, disability, sex, gender identity, gender reassignment, marital or civil partnership status, pregnancy or maternity, race, religion or belief and sexual orientation.