Artificial metalloenzymes for catalysing new-to-nature reactions

In the Rhys lab we design and engineer peptides and proteins for new applications. For this project we are looking for a PhD student who is interested in developing new enzymes to catalyse reactions that are not known to occur in nature. We will achieve this by designing and optimising Artificial Metalloenzymes (ArMs). ArMs are proteins that contain non-natural metal complexes. In this project we will synthesise transition-metal complexes that will be bound to highly stable proteins and explore cross-coupling reactions. Using these ArMs we will develop environmentally friendly alternatives to existing cross-coupling reactions, by catalysing reactions in water at near-ambient temperature using more earth-abundant metals.

You will be immersed in our recently expanding team who are developing artificial enzymes, where you will individually explore new chemical transformations.

It's an exciting time to research enzyme design because you will be joining a global community of scientists that is rapidly growing. During your PhD there will be opportunities for you to present your work at national and international conferences.

This project is ideally suited for anyone with a background in synthetic inorganic/organic chemistry or molecular biology and is looking to expand and develop their skills further. It is a highly interdisciplinary project where you will have the opportunity to develop skills in synthetic chemistry, chemical biology, molecular biology, structural biology, protein design and computational modelling. These are very desirable research skills that, upon completing your PhD, will make you suitable for a wide range of opportunities in academia or industry.

The Rhys lab is a supportive environment that cares about the development of its students and staff. We encourage you to apply regardless of age, disability, ethnicity, gender and sexual orientation. We are open to anyone looking to contribute to making the lab a diverse, inclusive and friendly environment.

For more information visit www.rhyslab.com

Supervisor - Dr Guto Rhys - People - Cardiff University

Start date options - 1st April, 1st July, 1st October 2024 or 1st January 2025.

Deadline for applications - Friday 12th January 2024.

All applications will be reviewed after the deadline. You will not hear from us until late January 2024.

Academic criteria

Applicants should have, or are predicted to have, a good grade in a university subject related to Chemistry or Biochemistry. For example, a UK 2.1 honours or US 3.2 (4-pt) GPA or higher.

English Language

If English is not your first language then you must fulfil our English Language criteria before the start of your studies. Details of accepted English Language qualifications for admissions can be found here https://www.cardiff.ac.uk/study/international/english-language-requirements/postgraduate

How to apply

Please complete an online application, stating your supervisor’s name(s).https://www.cardiff.ac.uk/study/postgraduate/research/programmes/programme/chemistry

For any further information please contact Dr Guto Rhys - [Email Address Removed]