University of Sheffield Featured PhD Programmes
Sheffield Hallam University Featured PhD Programmes
University of Edinburgh Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
The University of Manchester Featured PhD Programmes

Artificial metalloproteins as novel MRI contrast agents

This project is no longer listed on FindAPhD.com and may not be available.

Click here to search FindAPhD.com for PhD studentship opportunities
  • Full or part time
    Dr M M Britton
    Dr A Peacock
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Since MRI’s first clinical applications nearly thirty years ago, MRI has become an essential tool for clinical diagnosis. Image contrast is routinely enhanced by the use of a contrast agent (CA), with the overwhelming majority based on complexes of gadolinium, and more recently manganese.

However, current MRI CAs are limited by their small size (limits relaxivity, MRI efficiency) and inability to interact with biomolecules in a targeted fashion. In contrast, proteins satisfy both of these limitations, and thus, the goal of this project is to replace the ligands associated with traditional MRI CAs, with protein ligands.

Preliminary results have found that gadolinium complexes of miniature coiled coil protein scaffolds, see Figure, display superior MRI contrast capabilities compared to the traditional small molecular complexes currently employed in the clinic. This project will build on these findings, by engineering similar gadonlium (and manganese) sites into small proteins such as the family of knottin proteins, and larger assemblies with appropriate targeting opportunities.

This project builds on a long-term collaboration between the Peacock and Britton groups, bringing together expertise in peptide and protein design, synthesis and characterisation (Peacock) with MRI application and development (Britton). This powerful synergy will offer the student the opportunity to become expert in the broadest range of techniques and skills.

This studentship is competition funded by the BBSRC MIBTP scheme: http://www.birmingham.ac.uk/research/activity/mibtp/index.aspx

Please contact Dr Melanie Britton ([Email Address Removed]) or Dr Anna Peacock ([Email Address Removed]) directly for more information.

Deadline: 15 December 2019

Expected Stipend: £ 15,200 per annum (plus travel allowance in year one and a MacBook Pro)

The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.

To check your eligibility to apply for this project please visit: http://www2.warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/

Funding Notes

Expected Stipend: £ 15,200 per annum (plus travel allowance in year one and a MacBook Pro)

The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.

To check your eligibility to apply for this project please visit: http://www2.warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/

References

References:
[1] Berwick, M. R.; Lewis, D. J.; Pikramenou, Z.; Jones, A. W.; Cooper, H. J.; Wilkie, J.; Britton, M. M.; Peacock, A. F. A. “De Novo Design of Ln(III) Coiled Coils for Imaging Applications” J. Am. Chem. Soc., 2014, 136, 1166.
[2] Berwick, M. R.; Slope, L. N.; Smith, C.; King, S. M.; Newton, S. L.; Gillis, R; Adams, G.; Rowe, A.; Harding, S.; Britton, M. M.; Peacock, A. F. A. “Location dependent coordination chemistry and MRI relaxivity, in de novo designed lanthanide coiled coils” Chem. Sci., 2016, 7, 2207.

How good is research at University of Birmingham in Chemistry?

FTE Category A staff submitted: 28.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities


FindAPhD. Copyright 2005-2019
All rights reserved.